The toxic threat of Bisphenol A (BPA), an industrial chemical used in clear plastic bottles and linings for canned food, has long been known, and has been found, on multiple occasions, to be a carcinogen. A new study out of Duke University adds yet another bullet point to the dangers-of-BPA list. Interested in how environmental factors change the effectiveness of a drug (lapatnib) used to treat inflammatory breast cancer (IBC), a rare and particularly deadly form of cancer, the researchers exposed IBC cells to BPA in the presence of lapatnib and without. The results showed that not only was lapatnib less effective when BPA was present, but also, when the drug was absent, the cancer cells grew faster. Science Daily reports:
‘Routine exposures to common environmental chemicals like BPA appear to contribute to breast cancer cell progression and to diminish drug treatment efficacy, particularly in inflammatory breast cancer," said principal investigator Gayathri Devi, PhD, associate professor, Department of Surgery, Duke University Medical Center, Durham, N.C."
Read the full Science Daily report and find a link to the published journal article below.