Omega XL Review: Ingredients, Side Effects, Complaints, & More…

omega xl reviews

Welcome to my Omega XL review…

Omega XL is a popular Omega-3 supplement marketed as an excellent treatment option for joint pain and inflammation.

It claims to contain a powerful blend of omega-3 fatty acids and other natural ingredients scientifically proven beneficial for joint conditions.

Substantial evidence has shown omega-3 fatty acids to be excellent for heart and brain health.

Recent studies have also shown that omega-3s in fish oil may work for joint and back pain.

Omega XL claims to be “20x more potent than standard fish oil!” sourced from fish, krill, or algae.

Its blend of omega-3 fatty acids is derived from green-lipped mussels native to New Zealand.

Unlike other fish oil extracts, the green-lipped mussel lipid extract in Omega XL is richer in essential fatty acids.

Additionally, it does not give the fishy aftertaste common in standard fish oils.

According to the formulator, Omega XL contains more than 30 essential fatty acids potentially beneficial for people with arthritis.

In this Omega XL review, we look at different aspects of the much-hyped omega-3 supplement to determine its efficiency in relieving muscle soreness and joint discomfort caused by inflammation.

Our Recommendation

Omega KrillAfter a series of tests, we believe Zenith Labs Omega+Krill is the best joint pain supplement on the market.

Here’s why:

  • Zenith Labs Omega is 10x More Effective Than Omega XL
  • Helps you regain your joint flexibility in your fingers, back, and knees
  • It gives you healthier, more vibrant skin, nails, and hair…
  • Recommended by Medical Experts

So make sure to check it out. It might be the best money you’ll spend in 2024.

Omega XL – All You Need to Know

Omega XL Supplement

What is Omega XL

Omega XL is a natural joint supplement distributed by a company called Great HealthWorks, Inc.

Great Health Works (GHW) is a global natural wellness products manufacturer and direct-to-consumer distributor in Fort Lauderdale, Florida.

Omega XL is the company’s best-selling product.

Little wonder the founder and Chief Executive Officer of Great HealthWorks, Ken Meares, is particularly enthusiastic about the premium omega-3 supplement for joint pain.

Together with the company’s co-founder and COO, Miles DuPree, Ken Meares is said to be earnest and genuine about the well-being of people using his health products.

The same spirit is shown in how the company successfully markets its cornerstone product, Omega XL, to millions of users globally.

Part of the success can be attributed to the efforts of numerous celebrity endorsers, including famous personalities like Larry King, Ana María Polo, Jonathan Cheban, Blair Underwood, Tony Dovolani, and Angélica María.

Their doubtlessness when sharing their success stories with Omega XL helped promote the product in the omega-3 supplement market.

Thousands of Omega XL reviews online reflect this incredible passion and positivity.

Usually, a product does not receive a lot of attention and media hype if it is deemed ineffective in the slightest.

Still, you would ask how effectively Omega XL can relieve joint pain from osteoarthritis and rheumatoid arthritis.

Ultimately, this Omega xl review attempts to determine whether this supplement can help with joint pain and muscle soreness as it is advertised.

First, let us see how Omega XL works.

How Does Omega XL Work for Joint Pain Relief?

Omega XL supplement is a high-quality omega-3 supplement designed to naturally support joint health.

Marketing targets older adults with active lifestyles who may benefit from a reliable joint supplement to support their busy schedules.

This explains the company’s choice of older celebrities like broadcast legend Larry King and popular Latin-American TV personality Ana María Polo, among others, to spearhead the Omega XL marketing campaigns.

In truth, joint discomfort, aches, and soreness caused by arthritis are most common in adults over 40.

Depending on the type of arthritis, doctors prescribe pharmaceuticals or surgery for joint repair, replacement, and fusion.

Medications prescribed for arthritic symptoms include:

  • Painkillers (acetaminophen),
  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (ibuprofen),
  • Counterirritants, and
  • Biologic response modifiers (etanercept)

It is not uncommon for a healthcare provider to suggest natural approaches, including joint health supplements like Omega XL and similar premium joint pain supplements.

The best joint supplements are packed with natural ingredients clinically proven to relieve arthritis pain.

The most popular supplements for treating joint pain caused by osteoarthritis include turmeric, fish oil, glucosamine, chondroitin, and Boswellia.

Omega XL is claimed to reduce joint pain because it contains fish oil.

Essential nutrients found in fish oil have been found to provide potent anti-inflammatory effects.

Apart from fish oil, the Omega XL joint supplement contains other natural ingredients rich in antioxidants.

Research has indicated that antioxidants may enhance immune function and could be effective at reducing inflammation.

As such, Omega XL uses a two-pronged approach to combat joint problems:

  • Reducing joint pain and inflammation
  • Strengthening immunity and triggering the natural healing process

Omega XL formulators designed a unique blend of three natural ingredients scientifically tested to be safe and effective in dealing with joint discomfort in the short term and improving mobility over the long term.

Here’s a quick look at the ingredients in the Omega XL proprietary blend:

  • Green Lipped Mussel (Perna canaliculus) oil extract (PSCO-524)
  • Extra virgin olive oil,
  • d-alpha-tocopherol (vitamin E)

The following section will discuss the science behind these ingredients to determine whether the Omega XL product help with joint pain as it is claimed.

Omega XL Ingredients

Omega XL supplement comes in soft gel capsules containing 300mg of the proprietary blend.

The supplement facts label lists three core ingredients; fish oil extracts (green-lipped mussels), natural monounsaturated olive oil, and natural Vitamin E (d-alpha-tocopherol).

Shall we drill down a little into the three primary Omega XL ingredients?

1) Green Lipped Mussel (PCSO-524)Oil Extract

The health benefits of fish oil are irrefutable.

Medical science has shown that fish oil packs essential nutrients, including omega-3 fatty acids and several important vitamins and minerals that may help support heart, brain, and joint health.

Omega XL lists its largest percentage of ingredients as high-quality “fish oil” extract from the New Zealand Green Lipped Mussel.

Oil extract from the Green Lipped Mussel (PCSO-524) is richer in omega-3 fatty acids than its standard fish oil counterpart.

The manufacturer claims their extraction process yields more than 30 essential omega fatty acids not found in standard fish oil supplements.

Centuries of studies determined New Zealand mussels to be rich in anti-inflammatory omega-3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

According to the manufacturer, each Omega XL soft gel capsule contains 12mg EPA and 7mg DHA.

Evidence suggests that fish-derived omega-3 fatty acids EPA and DHA may help reduce inflammation and minimize the risk of chronic diseases.

Separate studies have associated green-lipped mussel extract with arthritis pain-relieving effects.

The extract has also been found to positively affect symptoms of Delayed onset muscle soreness (DOMS) and Attention Deficit Hyperactivity Disorder (ADHD), all of which have been associated with inflammation.

Animals may also benefit from the anti-inflammatory properties of green-lipped mussels.

Several studies observed dogs fed with a green-lipped-mussel-enhanced diet to have proper gait and improved motor function.

Canines with clinical joint symptoms scored better in a musculoskeletal examination conducted by a vet after combining green-lipped mussel (GLM) extract with their typical diet.

A 2013 clinical research trial on human subjects found that no more than 1-to-3g green-lipped mussel lipid extract was efficacious for osteoarthritis-related joint pain.

The study also concluded that green-lipped mussel oils were superior to fish and krill oils in alleviating joint pain in humans.

Some researchers have warned that taking more than 3000mg of fish oil or green-lipped mussel extract may be hazardous due to their potential blood-thinning effect.

Omega XL provides no more than 1200mg of oil extracts from New Zealand green-lipped mussels when taken as suggested.

1200mg GLM is a safe and effective dose to relieve joint pain, inflammation, and muscle soreness.

2) Extra Virgin Olive Oil

Olive oil is touted to have plenty of beneficial health effects.

The formulator claims that Omega XL is designed with natural monounsaturated olive oil.

Natural monounsaturated olive oil is clinically proven to be a safe and highly effective form of olive oil.

Researchers are particularly interested in studying olive oil for the proposed anti-inflammatory action of its natural chemical compounds called phenols (polyphenols).

Several research studies in animals and humans have attempted to identify the specific polyphenolic compounds responsible for the proposed health effects of extra virgin olive oil (EVOO).

Studies agree that the phenolic compound called oleocanthal showed the most promise for reducing joint pain and inflammation from osteoarthritis and rheumatoid arthritis for joint problems.

Oleocanthal found in EVOO was suggested to be as effective as pharmaceuticals such as aspirin and ibuprofen.

Olive oil also contains omega-3 fatty acids, which we have shown to fight inflammation and support various aspects of human health.

While more research is needed, extra virgin olive oil has also been found to aid the natural production of a chondroprotective glycoprotein found in the joints.

The glycoprotein called lubricin is a crucial component of synovial fluid which plays a lead role in joint boundary lubrication.

Coupled with the appropriate exercises, EVOO was suggested to promote joint function and prevent cartilage degradation.

Olive oil is also considered a relatively good source of vitamins, amino acids, and minerals, which may add to its beneficial effects.

The potential benefits of Vitamin E are discussed below since it is named as a primary Omega XL ingredient.

3) Natural Vitamin E

Natural Vitamin E is listed as d-alpha-tocopherol on a dietary supplement label.

Alpha-tocopherol is the most active form of Vitamin E in humans.

Its supplemental form may be extracted naturally from plant oils, including Olive oil.

As we have shown, the widely studied health benefits of Olive oil, and d-alpha-tocopherol also has numerous potential health benefits.

Researchers found d-alpha-tocopherol to be a potent antioxidant.

Its antioxidant properties are essential in the fight against cell-damaging oxidative stressors called free radicals.

As such, d-alpha-tocopherol plays a critical immune-boosting role which helps the body protect itself naturally.

Some researchers suggest that taking supplemental vitamin E may reduce inflammation.

Supplemental alpha-tocopherol intake has been suggested to help with inflammation and pain symptoms associated with osteoarthritis.

It is suggested that d-alpha-tocopherol may delay the progression of osteoarthritis by addressing oxidative stress and inflammation of the joint.

Other studies in animal models have suggested that the antioxidant agents in d-alpha-tocopherol may help joint function by stimulating cartilage cell growth.

However, further research is needed to assert the link between d-alpha-tocopherol and its anti-inflammatory or anti-osteoarthritis effect.

Most studies suggest doses of 3mg and 15mg per day.

Potential Side Effects: Is OmegaXL safe to use?

From a clinical laboratory perspective, ingredients used in Omega XL formulation are considered safe in healthy individuals when given in the correct dosage.

That is not to say, however, that the supplement itself is without any unpleasant effects.

You have to expect at least some form of digestive discomfort with any new supplement you take.

Intestinal gas bloating and flatulence are perhaps the most common gastrointestinal effects you’d experience during the adjustment period.

Gastrointestinal complaints with Omega XL may stem from the fatty acid content in the supplement.

The molluscan shellfish oil in its proprietary blend is a major concern among Omega XL users.

While the formulator claims that Omega XL does not contain clinically relevant levels of allergy-triggering antigens in shellfish, we advise caution if you have an allergic reaction to shellfish.

Omega XL may also prove problematic due to the blood-thinning effect of supplemental alpha-tocopherol.

However, as the alpha-tocopherol dosage in the supplement cannot be determined, we cannot say how it will affect someone already on a blood thinner, such as aspirin, ibuprofen, and warfarin.

We strongly advise consulting with your healthcare provider before any new dietary supplement.

More so if you are pregnant, breastfeeding, or already on medication for any other health condition.

Severe cases of allergies and side effects should be treated as an emergency.

Contact local emergency services immediately.

Overall, as we’ll see in most omega XL reviews, most users do not experience any significant side effects with this supplement.

Testimonials From Customers

The internet abounds with positive Omega XL product reviews.

Somehow, I have come to expect this of most dietary supplements.

Carefully combing the internet for some honest omega xl reviews, you will find mixed customer reactions about the product.

Still, there seem to be more positive reviews than negative comments about Omega XL.

Most user reviews mentioned that they were satisfied with the results they got from the joint supplement.

Only a few customers mentioned experiencing relief joint pain later than the eight weeks promised.

Most others felt significant relief from muscle soreness and joint pain as early as two weeks after taking the supplement.

Interestingly, some users claim that the omega-3 supplement may have improved their metabolism and helped them lose weight.

Note that obesity has been known to contribute to wear and tear in the hip and knee joints, and it is often pointed out as the number one culprit of joint pain in overweight individuals.

A few Omega XL reviews claim the GHW omega-3 supplement to be a miracle pill!

Some satisfied users recommended the product to those looking to buy Omega XL.

While Omega XL is far from a miracle product, many users claim to be using it for their dogs and find it to work for their pets’ joint problems.

While few, you will not fail to come across negative omega xl reviews online.

I figure negative reviews are expected since no supplement will have universal beneficial effects.

Most negative reviews for this omega-3 supplement cite the potential side effects.

Abdominal pain, nausea, heartburn, bad breath, loose stools, and diarrhea were the most common complaints with some people taking omega xl.

Premium cost and absence of noticeable relief of knee and back pain were also part of the complaints in some negative reviews.

I took the Omega xl until the bottle was empty with no results what else can I use.     

These are overpriced!

This product is awesome for relieving pain in my shoulders and some arthritic things, but the downside is it really creates a really bad breath.

Several weeks after taking 2 pills in the morning and two pills in the evening, inflammation was gone and is still gone. I also noticed that I was hungrier, but lost weight, so I guess it sped up my metabolism, another plus. I continue to take it.

Quick Overview: Is the supplement good for joint pain relief?

Our evaluation of the ingredients used in Omega XL has shown that the supplement has what it takes to treat or help reduce the intensity of joint symptoms.

Extra virgin oil in the Omega XL blend has also reduced inflammation.

Virgin olive oil is common in joint supplements due to the anti-inflammatory effects of its phenolic constituents.

A compound in virgin olive oil called oleocanthal is suggested to be as effective as ibuprofen in relieving joint pain.

Supplements containing PCSO-524®, the patented marine oil lipid extracted from green-lipped mussels, are touted to be highly effective for inflammatory conditions, including arthritis joint pain.

Supplementing with 1-to-3 gm of green-lipped mussel alone may help with joint discomfort and stiffness caused by an inflamed joint.

Green-lipped mussels are effective because they contain high-quality omega-3 fatty acids, which have been proven to possess potent anti-inflammatory properties.

Many clinical trials have demonstrated that a 300 μg/ml green-lipped mussel oil complex (GLMOC) with a similar nutritional profile to Omega XL significantly improved arthritis symptoms and helped promote joint function.

The GLMOC blend used in studies combined green-lipped mussel extract with olive oil and alpha-tocopherol in a specific ratio which may not be similar to what was used in the Omega XL formula.

Still, the GLMOC blend was shown to be more effective than a placebo of olive oil and another placebo of alpha-tocopherol, both of which were given in the same concentration present in the GLMOC blend.


  • Sustainably sourced ingredients
  • It contains important omega-3s plus 30 fatty acids
  • Proven to support joint health
  • Relieves muscle soreness
  • Helps with mobility
  • No fishy aftertaste
  • Free of common allergens
  • Easy-to-swallow soft gel capsule
  • Free bottle offer
  • 60-day money-back guarantee


  • It may be problematic for people with shellfish allergies!
  • Possible drug interactions with blood thinners

Cost & Where to Buy

Omega XL retails online on the manufacturer’s official website and third-party retailers, including Amazon.

Amazon offers the best price value for Omega XL because of a “subscribe and save” offer when purchased from the company’s storefront.

There is a free-bottle bonus when you buy Omega XL directly from the manufacturer.

The free bottle offer comes with an automatic subscription for the auto-ship program, which charges you for two bottles monthly.

Two 60-count Omega XL bottles make for a 30-day supply when taken as the manufacturer suggests.

The manufacturer offers a 60-day money-back guarantee, which may benefit those unsatisfied with the results and wish to get their money back.

Bottom Line

Omega XL is a high-quality fish oil supplement.

It contains the essential omega-3 fatty acids EPA, DHA, and 30 other free fatty acids (FFA).

Omega-3 fatty acids in Omega XL are derived from New Zealand green-lipped mussels, which are sustainably farmed in the “pristine waters of New Zealand.”

Much research supports the benefits of green-lipped mussel lipid extracts used in Omega XL formulation.

Other Omega XL ingredients have also been widely studied to support their potential benefit in arthritis pain relief.

Several research studies have shown the combination of core ingredients used in Omega XL to be effective for joints.

The internet abounds with positive reviews from Omega XL users.

Most people claim to experience relief from joint discomfort and muscle soreness after taking omega xl pills.

Negative reviews cite mild side effects and premium pricing but do not mention the fishy aftertaste common in standard fish oil supplements.