Andarine (S4 SARM): Side Effects, Uses, Safe Alternatives & More…

Anabolic steroids give a lot of help to the physical body.

They are substances that also prevent other medical conditions like muscle wasting, and one of these steroids include Andarine.

According to clinical trials in Ohio, the Andarine anabolic steroid can increase muscle strength and bone density.

However, some reports say that there are some dangerous side effects when it comes to this drug.

Because of this, alternatives are recommended, and in this article, you will find the best alternative for this steroid.

Andarine Safe & Legal Alternative

The best safe and legal alternative to Andarine (MK-2866) is Brutal Force ANDALEAN.

Here’s why:

  • ANDALEAN helps you cut through fat and build muscle
  • Smash through your max lifts and plateaus
  • Helps you gain strength faster than before
  • Burn through fat like butter

So make sure to check it out. It might just be the best money you’ll spend in 2024.

Andarine (S4 SARM): Everything You Need to Know

Andarine S4: What is it For?

As one of the selective androgen receptor modulators (SARMs), this synthetic product is used for the treatment of muscle wasting.

This drug is most popular in many users under the cutting phase as it can also help them manage their body weight.

It is an investigational drug that is not yet approved by the Food and Drug Administration and it is manufactured by the company GTx, Inc.

Andarine Indications

Generally, this drug binds to the androgen receptors and stimulates the skeletal muscles and bones to grow. Aside from muscle wasting, it is also used to increase bone mineral density. Other indications for this drug include:

  • Osteoporosis
  • Benign prostatic hypertrophy (prostate enlargement)
  • Obesity or excessive weight gain
  • Androgen deficiency
  • Sarcopenia
  • Prostate cancer and cancer cachexia

According to the company, Andarine is both a weight loss supplement and a performance-enhancing substance. Other names for this drug include GTx-007, S-4, and S-40503.

Who Should Avoid Andarine?

Although Andarine can provide many benefits to both bones and muscles, there are still some contraindications regarding it.

Some of these contraindications will be discussed in this section.

1) Pregnant and lactating women

In one scientific research published in The Journal of Endocrinology, the Andarine’s effect on the uterus has not been established. 

But since this selective androgen receptor modulator is still an investigational drug, it is not safe to say that it can benefit pregnant women as there is a possibility that it could cause harm to the fetus. 

2) Patients with blood disorders

In one case from the USA, it was reported that one of the side effects of SARMs such as Andarine is blood clots.

It causes suppression of clotting factors II, V, VII, and X. Eventually, this could lead to an increase in prothrombin time. 

Because of this, it is highly recommended for those with blood disorders to avoid this substance.

For safety, it is also advised for those taking this drug to check their hemoglobin and hematocrit levels, especially when they are taking higher doses of Andarine.

3) Patients with cardiovascular issues

Based on product reviews, there are some issues about the Andarine anabolic steroid’s effect on the heart. It causes stroke, making it not suitable for patients with cardiovascular issues.

Other effects of this drug on the heart include an increase in blood pressure and irregular heartbeat.

If patients with heart problems wish to take this drug, it is highly advised to seek medical consultation beforehand.

4) Those with mental illness

SARMs are known to be habit-forming.

Thus, patients with mental issues and those who have a history of drug addiction should avoid the use of this substance.

Take note that the Andarine anabolic steroid also targets the androgen receptors in the brain.

Thus, there is a high possibility of brain structure changes from using this substance.

Consistent with one scientific study from Miami, the Andarine anabolic steroid causes mood swings. 

The Cons of Andarine S4

Apart from the contraindications, there are also some disadvantages of using or purchasing the Andarine anabolic steroid. Usually, these disadvantages are the side effects, and in this section, we will discuss each of these.

1) Acne breakout

The use of Andarine, like many other SARMs, could cause acne breakout, especially when you are acne-prone.

These steroids affect your hormone levels, leading to hormone imbalances.

According to a study in India, your hormone affects the origin of your acne breakout, and these origins include androgens and estrogens.

2) Irregular heartbeat

Based on the report of the Health Sciences Authority (HSA), Andarine is a SARM that is associated with serious side effects on the heart.

This drug may cause an increase in blood pressure and irregular heartbeats.

Some reports even state that this drug causes a heart attack. This means that those who are taking this substance are at a high risk of ischemic stroke.

3) Irritability

There are also some reports about this drug causing psychological effects. Also based on the HSA report, Andarine causes irritability and mood swings. Other SARMs are used to balance mood swings but this one is an exemption. 

4) Dry mouth, lips, and altered vision

Aside from headaches, other most common side effects of using Andarine include dry mouth and lips.

In some reports, there are also cases of altered vision, called yellow-tinged (xanthopsia).

Patients with this health condition experience a predominance of yellow tint in their vision making the users have a hard time adjusting to night vision.

This occurs because the optical media of the eye start to become yellow.

5) Liver injury

As cited by the US Pharmacist, it was reported that this Andarine anabolic steroid causes liver injuries.

In this case, it was reported that a man, age 24, displayed signs of hepatocellular liver injury.

Furthermore, these liver injury symptoms appeared one week after stopping the drug.

What is more interesting is that this man has no history of binge drinking, does not take any maintenance drugs or substances, and has no history of previous liver dysfunction.

What People Say About This Selective Androgen Receptor Modulator

Moving on, it is also important to learn what other people say about the Andarine anabolic steroid. Since the Andarine is not FDA approved.

This means that it is not yet approved for human use and taking it should be for research purposes and clinical trials only.

To understand more about the Andarine anabolic steroid, let us take a look at some Andarine user reviews below:

Based on the reviews above, the common report of the users is that this drug can cause an increase in muscle mass.

It is an effective bulking and cutting substance as it can also promote fat loss.

One user even reported that he was able to maintain healthy muscle gains even after using the substance. Indeed, this drug can improve body composition and athletic performance!

Furthermore, there is also a user report that this drug can increase energy levels.

Thus, for potential buyers of the Andarine anabolic steroid, taking it would surely help you increase your muscle growth, enhance your bone mineral density, and can help you lose weight.

What We Like About This Anabolic Steroid

There are also some advantages of using the Andarine anabolic steroid, and in this section, we will discuss what are the benefits this drug could provide.

1) Reduce prostate weight

As a partial androgen receptor agonist, in animal studies from the United States, it was reported that this drug reduced the prostate weight of intact male rats and castrated male rats.

For the latter group, there was also an increase in muscle weight.

This study suggests that this Andarine can competitively block binding of dihydrotestosterone, an androgen responsible for stimulating the male characteristics,  to its receptor targets.

Additionally, being a partial androgen receptor agonist, it prevents the side effects of an androgen receptor antagonist being used for the treatment of benign prostatic hypertrophy.

2) Enhance muscle growth and prevent muscle degeneration

Muscle degeneration decrease in muscle mass is associated with aging. Based on clinical trials from Los Angeles, per decade, muscle mass decreases at a rate of 3-8% after the age of 30. This rate of decline is even higher after age 60.

Fortunately, the Andarine anabolic steroid can help build muscles and maintain healthy muscle growth even as you age.

If you feel like losing mass, you can consider Andarine or other anabolic drugs as long as your medical condition suits them.

Based on clinical studies from California, it was reported that Andarine is beneficial to the physical body of patients with HIV who are experiencing muscle mass loss.

3) Reduction of body fat

One great thing about the Andarine anabolic steroid is that it can reduce body fat, and by promoting this fat loss, obese patients can benefit from it.

Generally, it works by stimulating the natural thermogenesis of the body, causing the body to burn fat.

There are some reports that this Andarine drug can be used for the treatment of class I, II, and III obesity.

Another use of this drug that is related to body fat includes weight reduction caused by water edema.

4) Cancer treatment

There are many cancer types that Andarine could treat. Some of these include prostate gland cancer and cancer cachexia.

Both of these cancer types can lead to a loss of muscle mass.

Fortunately, the Andarine anabolic steroid can help maintain these muscles.

For those with bone cancers, this drug can also help increase bone density. 

For the cancer cachexia, it was reported that the anabolic steroid Andarine helps cancer patients keep their muscles healthy by reducing the risk of muscle wasting.

Take note that when there is muscle wasting, patients would become more at risk of falls and fractures.

To avoid this, the use of anabolic steroids would be of great help.

5) Chemically stable

One thing we like about the anabolic steroid Andarine is its formulation.

Although its legal status is still an investigational drug, the chemical property of this drug is stable compared to other chemicals.

Its molecular weight is 441.36 and its chemical formula is C19H18F3N3O6.

According to the company, this drug has a safety profile that can provide all the health benefits to the body, including increased muscle vascularity and strength.

Another great thing about it is that it comes with a short half-life, around 4 hours.

This means that it rarely causes a false-positive result on drug tests compared to other substances.

However, unless this drug is approved by the FDA, this may not be confirmed. To learn more about its scientific data, you can click here.

What to Watch Out For When Buying SARMs

Athletes and bodybuilders tend to look for the best supplements for their cutting cycles or for improving their athletic performance, and one of their choices will surely include anabolic steroids like Andarine. 

However, although this drug can provide many health benefits, it still comes with dangerous side effects such as acne breakout, irregular heartbeat, irritability, dry mouth, lips, altered vision, and liver injury.

Among these, the most dangerous one is liver injury as it can cause permanent liver damage. 

Also, there are many contraindications with this drug, and only those 18 years old and above can take it for whatever legal purpose.

If you want to know more about Andarine, you can click here.

Drug Interactions with Andarine S4

There are also drug interactions when it comes to the Drug Andarine. Some of the drugs and substances that may interact with this drug include the following:

  • Itraconazole
  • Rifampin
  • Probenecid
  • Celecoxib
  • Rosuvastatin

To avoid health complications, it is highly advised for bodybuilders and athletes who use Andarine to seek information from a medical doctor before taking this drug together with other medications or supplements.

The dosage of Andarine should also be determined by a health professional. Keep in mind that dosage and side effects are related.

Buying Guide

There are many steroid drugs all over the net and one of these includes the Andarine S4. However, athletes and bodybuilders should not be swayed by this information.

In this section, you will have a complete buying guide that can help you optimize your money.

Andarine Dosage and Route of Administration

Beginners take lower doses of this drug, around 25 mg daily dose. At this dosage, Andarine can already boost strength, increase lean muscle mass, and promote fat loss.

Many bodybuilders also love to stack this drug with Testolone, at a dosage of 10mg.

Again, this dosage may change depending on the health condition of the user. Stacking these supplements can improve the function of your body and overall wellness better.

Safe Alternative to Andarine

SARMs like Andarine are currently officially banned because they are not yet approved by the FDA but are still available in the black market.

Additionally, these are prohibited substances by the World Anti-Doping Agency.

So, companies in the supplement industry formulated safe alternatives like the Andalean by Brute Force.

This supplement can provide the following benefits:

  • Increased testosterone levels
  • Enhanced muscle gains
  • Boosted energy levels
  • Long-lasting workouts
  • Improved cognitive function
  • Faster recovery time

You can buy this supplement from the official website, and purchasing it there gives you many procurement benefits such as free shipping, a 100% 60-day money-back guarantee, and a 20% discount when you subscribe using your email.

To use this supplement, take 4 capsules 20 minutes before your workout.

For better results, use this supplement in conjunction with a healthy diet and regular exercise.


Indeed, the use of the anabolic steroid Andarine can improve your physical performance. Many cancer patients, especially those with prostatic cancer would surely benefit from it,

However, there are some contraindications when it comes to this drug such as those with cardiovascular problems.

This drug can cause irregular heartbeat which could lead to a heart attack.

Thus, the use of a safer alternative called Ligan 4033 is highly recommended.

Manufactured by the company Crazy Bulk, this supplement can provide the same benefits as using Andarine while causing no side effects.

If you wish to purchase this supplement, you can check out the official website for many promos.

Frequently Asked Questions (FAQs)

How does Andarine affect prostate cancer?

Andarine is a beneficial drug for those with prostatic cancer. It works by shrinking the cancer cell and suppressing the androgen effects.

What are the advantages of using Andarine?

Andarine comes with many uses such as treatment and prevention of cancer, enhancement of muscle mass, promotion of fat loss, and proper weight management.

Does Andarine require a PCT?

Like the other SARMs, Andarine also requires a PCT or post-cycle treatment to clear off any negative effects of the drug.