Ligandrol Review (LGD-4033) – Uses, Side Effects, Results, & Alternatives…

ligandrol review lgd 4033
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Aging causes your muscles to become weak. Eventually, this can lead to a decline in physical performance.

Fortunately, selective androgen receptor modulators like Ligandrol are effective in increasing your muscle strength.

According to a study from Germany, the Ligandrol anabolic steroid is used to increase muscle mass and vascularity.

In this article, you learn more about Ligandrol LGD-4033 and what is the safest alternative supplement you can use.

Ligandrol Safe & Legal Alternative

The best safe and legal alternative to Ligandrol (LGD-4033) is CrazyBulk LIGAN 4033.

Here’s why:

  • LIGAN 4033 lifts testosterone naturally— no suppression
  • Helps you preserve muscle mass
  • Increases your muscle size
  • Melts your fat & reveals your shredded physique

So make sure to check it out. It might just be the best money you’ll spend in 2022.

Ligandrol: Everything You Should Know + Safe Alternatives

What is Ligandrol LGD-4033

Also known as Ligandrol, VK5211, or Anabolicum, this substance is an investigational drug that is used as a pharmaceutical treatment for muscle wasting.

It also affects the bones by increasing bone density.

This selective androgen receptor modulator was discovered by Ligand Pharmaceuticals under the development of Viking Therapeutics located in San Diego.

According to Ligand Pharmaceuticals, also situated in San Diego, this drug could benefit professional athletes.

Furthermore, according to the Research and Development Costs, Viking Therapeutics assumed the largest expense in this drug.

The funding is also associated with the equipment to be used in developing the drug candidates licensed by Ligand Pharmaceuticals.

Currently, the drug is under phase II clinical trials. In the first clinical trials of Ligandrol LGD-4033, there were no side effects reported. 

Ligand Pharmaceuticals started in the health and wellness industry in 1987.

The company is known for its innovator drugs Kyprolis, Promacta, Melphalan, and Baxdela.

Ligandrol Indications

Generally, Ligandrol LGD-4033 is mainly used for enhancing muscle mass.

It promotes healthy muscle growth, and aside from increasing muscle strength,  this drug is also used for the following indications:

  • Osteoporosis or other bone health issues
  • Bodyweight management
  • Fatigue

According to Ligand Pharmaceuticals, the use of this drug is not limited to bodybuilders and athletes. Instead, this drug is also suitable for cross-fitters, models, and gym enthusiasts.

Can Everyone Use this Selective Androgen Receptor Modulator?

Although Ligandrol LGD-4033 can increase muscle mass, not all interested individuals who want to try this drug can use it.

There are some contraindications with Ligandrol LGD-4033, and in this section, we will discuss each of them.

1) 18 years old below

According to Ligand Pharmaceuticals, this selective androgen receptor modulator should only be used by adults 18 years old and above.

For users below 18, it is highly advised to seek consultation from a medical doctor beforehand to avoid dangerous adverse events.

2) Pregnant and lactating women

Ligandrol LGD-4033 falls under pregnancy category X. This means that it comes with teratogenic effects which may harm the fetus.

Aside from this, Ligandrol LGD-4033 is still an investigational drug. Thus, there are no clear reports that these anabolic steroids are safe both for the pregnant mother and child.

Take note that most anabolic steroids are contraindicated to pregnant and lactating women. So, for safer use, avoid this substance at all times during pregnancy.

3) Cardiovascular disorders

One of the adverse effects of Ligandrol LGD-4033 includes an increase in blood pressure, and many users have reported this already.

So, for patients with cardiovascular disorders, this drug might not be suitable for them.

Based on other reports, the Ligandrol LGD-4033 can also cause heart attack and irregular heartbeat.

4) Those with mental health illness

Take note that Ligandrol LGD-4033 targets the androgen receptors in the brain.

This means that it can cause hormonal imbalance that may alter your mood.

Based on some reports, the Ligandrol LGD-4033 comes with some mental adverse effects like anxiety and mood swings.

Usually, anabolic steroids are used to balance hormone levels. However, Ligandrol LGD-4033 does the opposite.

The Cons of Ligandrol LGD-4033

Apart from the contraindications, there are also some disadvantages of using Ligandrol LGD-4033. In this section, we will discuss each of them.

1) May need PCT

Like most anabolic androgenic steroids, the use of Ligandrol LGD-4033 also requires PCT or post-cycle therapy.

This is a cycle where users of anabolic steroids take a time off these drugs to restore their natural production of testosterone.

2) Drug-induced liver injury

There are many reports about anabolic steroids causing liver injuries.

According to a clinical trial in Slovakia, Ligandrol LGD-4033 may cause liver toxicity characterized by cholestatic liver injury with prolonged recovery.

In one case report from Texas, it was reported that a patient without any history of medical problems was admitted to the hospital due to elevated liver enzymes and jaundice.

The symptoms of this liver injury include the following:

  • Itching
  • Jaundice
  • Alcoholic stool
  • Intermittent abdominal pain associated with nausea

Because of this, longer randomized trials are highly recommended to confirm the safety and effectiveness of the drug in improving physical function.

Ligandrol promotes a dose-dependent increase in liver injury risk.

To avoid these serious consequences, it is highly advised to avoid the use of this drug, especially if you have a pre-existing or previous liver disorder.

3) Other side effects

Aside from altering your mood, the Ligandrol LGD-4033 can cause many serious adverse events. Some of these include nausea, fatigue, headache, alopecia or hair loss, and low libido. 

Some reports say that these side effects are due to low testosterone levels.

Consistent with a study from Boston Medical Center, it was stated that although this drug can increase lean muscle mass, the oral administration of Ligandrol LGD-4033 can suppress total testosterone levels in healthy young men. 

In this placebo-controlled study from Boston Medical Center, the primary endpoint for test subjects is to get an improved lean body mass, and the drug group was able to achieve this.

Ligandrol LGD-4033 can suppress testosterone levels.

As we all know, when a person has low T-levels, this could make the symptoms stated above appear.

Other side effects include significant body weight gain when taken at higher doses. 

What People Say About this Selective Androgen Receptor Modulator

Ligandrol LGD-4033 is one of the potent anabolic steroids that is used to increase athletic performance.

It is a promising drug candidate to treat many health disorders.

But, before believing that, let us take a look at what users of Ligandrol LGD-4033 say about this drug.

Based on the reviews above, the users said that Ligandrol LGD-4033 is an effective drug to increase muscle mass and muscle strength.

It can maintain and preserve muscles, making it truly beneficial for the bodybuilding community.

However, it comes with certain side effects such as testosterone suppression, water retention, lethargy, low energy, depression, and low libido. 

Based on the reviews above, these side effects are also associated with an absence of PCT or post-cycle treatment. 

Usually, the users take an 8 weeks cycle with a dose of 10 mg per day. Some users also take Ligandrol together with other supplements like MK-677. 

For potential users of this drug, it is safe to say that Ligandrol can help you improve your athletic performance by preventing muscle wasting and promoting healthy lean body mass.

There are no reports that this drug can burn body fat.

Also, varying dose sizes depend on the preference of the user.

You can take this drug in daily doses varying from 5 mg or 10 mg, and for better health outcomes, it is highly recommended to take this supplement with a proper diet.

Lastly, taking this drug with a dietary supplement or other anabolic steroids could provide a better lean body mass. 

What We Like About this Anabolic Steroid: The Pros of Ligandrol LGD-4033

Apart from the health risks, we will also discuss the advantages of using Ligandrol LGD-4033.

This nonsteroidal oral drug is an effective substance that can improve your overall physical function. 

But, considering that it has a favorable pharmacokinetic profile, has undergone mass spectrometry, and does not affect the prostate-specific antigen, what does this drug do to your body?

1) Increase lean muscle mass

One of the anabolic effects of Ligandrol is that it can cause an increased lean body mass and many users take it to increase their athletic performance.

It can also increase muscle growth and muscle strength. 

According to the users of this drug, Ligandrol can also increase energy levels.

So, if you are looking for a muscle mass enhancer with this anabolic activity, you can consider the LGD-4033, as long as you are healthy.

2) Bone healing

One great thing about the anabolic activity of the LGD-4033 is that it can promote bone healing and speed up fracture recovery.

It works by targeting the androgen receptors in the muscles and bones, making it suitable for patients with osteoporosis, tendonitis, and arthritis.

In one clinical trial from China using a randomized study, participants who have undergone hip fracture surgery also benefited from LGD-4033. 

3) Treatment for cancer

Aside from the anabolic effects of LGD-4033, it is also beneficial for cancer patients, especially those with breast cancer.

This makes this drug interesting for professionals in biological sciences and medical sciences.

Some reports say that LGD-4033 can also be a treatment for prostate cancer without affecting the prostate-specific antigen.

However, if the dosage is improper, it may only worsen the health condition of the patient.

With this LGD-4033 designed for cancer, it surely can reduce the risk of muscle wasting and muscle damage caused by cancer in these groups of patients.

4) Weight reduction

Another use of LGD-4033 is for weight reduction.

It works by stimulating the body’s thermogenesis, thereby burning body fat to make your body more defined. 

However, to achieve this effect, you should take this drug at a low dose.

Taking it at a higher dose can cause weight gain, especially when taken for a long period.

What to Watch Out for When Buying Ligandrol

Before buying this anabolic steroid, there are some important things to be noted. In this section, you will know if this substance is suitable for your health.

Although LGD-4033 offers many health benefits, there are also some side effects. These side effects include the following:

  • Testosterone suppression
  • Water retention
  • Lethargy
  • Low energy
  • Depression
  • Low libido
  • Nausea
  • Headache
  • Alopecia or hair loss

Additionally, since this LGD-4033 is still an investigational substance currently having ongoing clinical trials, it is not safe to be used by those below 18 years old.

Also, although it can treat cancer, too much dose of it can worsen the condition. Lastly, this LGD-4044 may be used to reduce weight.

However, at higher doses and longer use, it can only promote weight gain.

To understand more about this LGD-4033, you can click here.

Buying Guide for Anabolic Steroids

There are many Ligandrol available in the online market even if this drug is a forbidden substance by the FDA.

Because of this, you must be sure that the one you buy is safe and effective.

In this section, you will have a buying guide that can help you optimize both your health and your money.

LGD-4033 is available in oral and injectable form, and the usual dosage is around 5-10 mg per day, depending on the health condition of the patient. 

Additionally, it is worth mentioning that LGD-4033 can cause a false-positive result on a drug test.

Systemic exposure to this drug can make the substance last on the body for a week, and it has a prolonged elimination half-life of up to 32 hours.

Because of this, many athletes were suspended due to testing positive for Ligandrol. 

Some of these athletes who were suspended for testing positive on LGD-4033 were Shayna Jack and Will Grier.

Aside from these two, Lauren Lapointe also tested positive for LGD-4033. This athlete denies knowingly taking this substance.

There was also an issue about this drug, being misbranded. The company received a warning letter from the FDA as this LGD-4033 is lacking the required approved applications.

The Legal Ligandrol Alternative: Ligan 4033LIGAN 4033

LGD-4033 is a nonsteroidal oral banned substance by the World Anti-Doping Agency.

Aside from not being approved by the FDA, its dosage can also negatively impact development.

Because of this, many athletes start to look for alternatives, and if you are one of them, you might want to consider the Ligan 4033 by Crazy Bulk.

According to the company, this drug can promote better benefits than Ligandrol. Some of these include:

  • Increased testosterone levels
  • Muscle gains
  • Improved workout performance
  • Boosted energy
  • Reduced muscle recovery time

Crazy Bulk believes that this dietary supplement can make a major shift in the safer use of anabolic steroids.

When you buy from the official website, you could get many procurement benefits such as free shipping, a 100% 60-day money-back guarantee, and a 20% additional discount upon subscribing using your email.

Also, when you buy 2 bottles of the Ligan 4033, you will get another bottle for free. If you buy 3 bottles, you will get another 2 bottles for free.

Take note that one bottle of Ligan 4033 can last for a month.

So, when you buy 3 bottles, it is like you are buying a free 2 months supply.


Indeed, Ligandrol is an effective substance that can enhance your physical function.

It comes with many benefits, especially to the muscles and bones. 

However, not all people can use this.

There are contraindications when it comes to this drug and these include those below 18 years old, pregnant and lactating women, those with cardiovascular disorders, and those with mental health problems.

There are also some side effects of using this drug such as fatigue, low libido, and testosterone suppression.

Because of this, a safe alternative called Ligan 4033 was formulated.

This is an all-natural supplement that mimics the effect of the anabolic steroid.

If you want to purchase it, you can check out the company’s official website for a safer transaction.

Frequently Asked Questions (FAQs)

What are the common side effects of using Ligandrol?

The most common side effects of taking this anabolic steroid include nausea, low libido, and headaches. Many experts believe that these are associated with low testosterone levels.

Is Ligandrol hepatotoxic?

Yes, the anabolic steroid Ligandrol can cause liver damage. Thus, those with a history of liver conditions or preexisting liver disorders should avoid this drug.

What is the dosage for Ligandrol?

The dosage depends on the instruction of your healthcare provider. However, most users of Ligandrol take 5 to 10 mg of this drug per day, for 8 weeks. Some users also stack it with other anabolic steroids and dietary supplements.