Home Bodybuilding MK677 SARM Review: Ibutamoren MK-677 Dosage, Side Effects, Safe Alternatives

MK677 SARM Review: Ibutamoren MK-677 Dosage, Side Effects, Safe Alternatives

Written by Decyry Jhoy Serrano, RPh

Patients with HIV are prone to muscle wasting that causes a decline in athletic performance.

Fortunately, anabolic steroids such as Ibutamoren can manage this.

Based on clinical studies from Texas, it was reported that the anabolic effects of Ibutamoren MK-677 can enhance muscle strength, increase athletic performance, and support the immune system.

In this article, you will learn more about the anabolic steroid Ibutamoren MK-677 and the legal alternative for this substance.

Ibutamoren Safe & Legal Alternative

The best safe and legal alternative to Ibutamoren (MK677) is IBUTA 677.

Here’s why:

  • IBUTA 677 is Legal & Natural MK 677 Alternative For More HGH
  • Naturally increases HGH
  • Promotes muscle fullness
  • Supports fast recovery

So make sure to check it out. It might just be the best money you’ll spend in 2022.

Ibutamoren MK 677: Dosage, Side Effects, Safe Alternatives

What Is Ibutamoren MK-677?

Ibutamoren, also known as MK-677, MK-0677, L-163, L-191, or Oratrope, is a growth hormone (GH) secretagogue that comes with anabolic effects.

Mainly used to increase muscle mass, this drug is also used to promote fat loss.

Ibutamoren MK-677 was first discovered in 1995.

It is one of the research chemicals under selective androgen receptor modulators and it works by promoting growth hormone levels.

A growth hormone (GH) is produced by the pituitary gland that can provide many health benefits to the human body.

Ibutamoren Indications

Based on human studies from the journal of Clinical Endocrinology (Oxford), growth hormone secretagogues increase serum prolactin levels, and aside from enhancing your lean muscle mass, these drugs are also used for the following indications:

  • Insomnia
  • Obesity
  • Osteoporosis
  • Cardiovascular support

This oral growth hormone secretagogue is also used for wound healing. According to a study from Boston, Ibutamoren MK-677 speeds up the skin’s recovery from scars.

Many users also take this nonpeptide growth hormone secretagogue to improve thicker and stronger hair.

Can Everyone Use this Growth Hormone Secretagogue?

Although this drug for growth hormone deficiency can provide many health benefits, it is not suitable for all individuals.

There are some contraindications when it comes to Ibutamoren MK-677 and in this section, we will discuss some of these.

1) Elderly population

Based on a clinical review, Ibutamoren MK-677 is contraindicated to patients above 65 years old.

This is a disadvantage to elderly people who are using anabolic steroids to improve their physical function. 

This also means that there is insufficient information about the safety of this novel growth hormone secretagogue in healthy elderly subjects.

2) Patients with a history of seizure

Also based on the source above, Ibutamoren is not suitable for patients with a history of seizures.

The IV administration of Ibutamoren MK-677 to healthy young adults produced seizures and loss of consciousness. 

Consistent with a study from Korea, the growth hormone profile of Ibutamoren MK-677 caused seizures in animal subjects when taken with the drug pilocarpine.

This simply means that there are also drug interactions with this growth hormone drug. 

3) Pregnant and lactating women

Just like the other SARMs, this growth hormone secretagogue is not yet approved by the FDA.

It is under pregnancy category X, meaning, it has teratogenic effects. 

Although Ibutamoren MK-677 is effective for growth hormone deficient children, this drug has not been tested in pregnant and lactating women.

Since the clinical trials for Ibutamoren MK-677 exclude this group of people, it is safe to say that this drug is not safe to use by these patients.

The Cons of Ibutamoren MK-677

Apart from the contraindications, there are also disadvantages of using Ibutamoren MK-677.

Most of these are serious adverse effects and some reports say that these side effects are similar to those of drugs for growth hormone therapy.

In this section, we will discuss each of these side effects.

1) Fluid retention

One of the major side effects of using Ibutamoren MK-677 is edema, and 44% of those who are using it can experience this.

This edema is mild and may be mistaken for lean muscle mass gains.

You can see significant changes in your body composition but these might be due to the edema.

Based on a study from the United States, this edema is usually on the lower extremities and it comes with muscle pain.

Usually, this edema occurs when Ibutamoren MK-677 is administered by injection.

2) Insulin-like growth factor stimulation

Insulin-like growth factors are associated with obesity and diabetes and the growth hormone secretion effects of Ibutamoren cause stimulation of the insulin-like growth factor.

Eventually, this could lead to reduced insulin sensitivity. 

Always keep in mind that growth hormones can increase the risk of diabetes.

In one study from London, it was confirmed that filling the body with growth hormones can increase blood glucose levels.

Although effective for managing hypoglycemia, the improper dosage of this drug can cause health dangers.

3) Carpal tunnel syndrome

Carpal tunnel syndrome also happens when it comes to taking Ibutamoren and around 10% of Ibutamoren users experience this.

According to a study from Wisconsin, this joint pain is usually seen in women and usually, this side effect is seen during the prolonged oral treatment of Ibutamoren MK-677.

There is no definite remedy for this side effect yet, but many Ibutamoren users consider using wrist splints to reduce the pain.

To learn more about the best carpal tunnel wrist splints, you can click here.

4) Increased appetite

Another thing to consider when taking Ibutamoren is that this drug can increase your appetite.

Thus, those who want to control appetite or experience weight loss may not appreciate this substance, and around 67% of those Ibutamoren users experience this side effect.

Generally, Ibutamoren stimulates the hormone ghrelin. Eventually, when the ghrelin receptor is activated, your hunger hormone will also be activated.

What People Say About MK-677: Ibutamoren Reviews

Ibutamoren offers a promising potential therapy for building muscle mass, that is why many athletes and bodybuilders take this substance.

To see the effectiveness of this drug in promoting healthy muscle growth, let us take a look at what these users say about Ibutamoren.


Based on user reports, Ibutamoren can effectively increase lean body mass. Within 6 weeks, these users already saw positive changes in their bodies. 

Additionally, users also take this drug with Ligandrol. Although PCT is not required, other users who cannot tolerate the effects of the drug have used Clomid as a PCT drug.

Based on the users above, the dose of Ibutamoren is 10-25 mg per day.

When it comes to side effects, only one user reported water retention or edema. As stated, this edema may be mistaken for muscle gains.

One user also reported that this drug may increase energy levels as it reverses diet-induced catabolism.

For potential users of Ibutamoren, this drug can reduce body fat and promote muscle gain.

Although none of the users report that this prevents muscle atrophy and increases bone density, those with growth hormone deficiency may appreciate this drug.

What We Like About this GH Secretagogue: The Pros of Ibutamoren

If there are contraindications and disadvantages, there are also many benefits to using Ibutamoren.

This drug stimulates growth hormone production, thereby producing the benefits listed in this section.

1) Healthy skin

One great thing about Ibutamoren is that it can enhance skin health.

As stated above, this drug can make the hair stronger and thicker.

Aside from this, it can also reduce skin scars due to the increase in the level of growth hormones.

Some reports say that this drug has antioxidant effects which can also support the immune system. 

2) Bone density support

Ibutamoren enhances bone turnover and bone mineral density.

In one clinical trial from New Jersey using selected GH deficient adults, it was reported that daily Ibutamoren increased GH and improved bone health by inhibiting bone resorption, thereby producing enhancement of bone mineral density in postmenopausal women. 

With this information, it is safe to say that this drug is of great help for patients with osteoporosis, arthritis, tendonitis, and other bone and tendon inflammation issues. 

3) Lowers the body’s LDL cholesterol levels

The GH secretion effects of Ibutamoren can increase lean body mass and reduce fat mass while lowering bad cholesterol.

Based on some reports, this drug stimulates the brain regions responsible for metabolic activity of the body.

With this, this drug may come with possible antilipidemic effects but this is not yet proven.

4) Improves sleep quality

The GH secretion effects of Ibutamoren increase rapid eye movement (REM) by binding to ghrelin receptors in the brain.

Also, this REM stage is important for learning and memory.

By taking Ibutamoren, you do not just enhance your sleep quality but your cognitive function as well.

In one study from Belgium, oral administration of Ibutamoren increased the duration of sleep by 50% and REM sleep by more than 20%.

Although this makes it look like Ibutamoren is a promising therapy for patients with insomnia or sleep disturbances, it is highly recommended for patients with these conditions to seek consultation from a medical doctor for safer use of the drug.

5) Growth hormone deficiency treatment

Patients who do not use MK-677 to gain fat-free mass take this drug instead to manage their growth hormone levels.

Eventually, when a patient does not have enough growth hormone levels, this could cause decreased sexual desire.

Having said this, MK-677 may also be one of the possible treatments for patients with sexual dysfunction.

What to Watch Out for When Buying MK-677

If you are an athlete, bodybuilder, or gym enthusiast, you should know if the effects of MK-677 are suitable for your health.

Although the increase in growth hormone effects of Ibutamoren provides many health benefits like improvement of cognitive function, reduction of body fat, an increase of bone density, and enhancement of sleep quality, there are also some side effects like fluid retention.

Additionally, this drug is only tested on patients between 21 to 65 years old. Those groups outside this range should avoid this substance.

To learn more about Ibutamoren, you can click here.

Buying Guide for MK-677

Although MK-677 is not yet approved by the FDA, many users still patronize it.

However, before buying this drug from the online market, you should have an idea about what this drug offers you.

With regards to its route of administration, MK-677 is available orally and through injection. The dosages of this drug are as follows:

  • Oral MK-677 – 10 mg
  • Injectable MK-677 – 10mg/ml

Take note that there is no official dosing guideline for MK-677.

The dosage will still depend on the health condition of the patient and his or her body goals.

Keep in mind that the dosage should fit the user as too much of this drug can cause an overdose.

The Legal Ibutamoren Alternative: IBUTA 677


Since buying MK-677 is not approved by the FDA and buying it online for recreational purposes is illegal, many athletes look for alternatives.

One of the best legal alternatives for this drug is IBUTA 677.

This supplement is manufactured by the company Crazy Bulk and it is mainly used to increase growth hormone levels.

Since this drug can increase growth hormone levels, it can also be used to balance mood and maintain healthy sexual functions.

It works by stimulating muscle protein synthesis, thereby producing positive effects on the muscles such as muscle fullness, vascularity, and recovery.

This supplement is also rich in Zinc, making it an effective medication to increase bone density.

IBUTA 677 Formulation

The formulation of IBUTA 677 is all-natural. It is made with vitamins, minerals, and amino acids that can enhance your overall health.

The ingredients of this supplement include the following:

  • Zinc – This ingredient improves bone health, metabolism, and nerve function. It is also used to support the immune system as it comes with antioxidant and anti-inflammatory effects.
  • Vitamin B5 – This vitamin helps your body burn fats and carbs. These fats and carbs, then, will be used as your source of energy.
  • Amino acids l-arginine HCl, glycine, l-glutamine HCl, l-lysine HCl, l-ornithine HCl, and l-tyrosine  – These amino acids are used to increase muscle mass. They help your body repair and build new healthy muscle fibers.

Before taking this supplement, it is highly advised to check if you have any sensitivities with the mentioned ingredients above.

Although this drug is safe to use, allergic reactions are dangerous to health.

IBUTA 677 Safe Use

Although there are no major side effects when it comes to the IBUTA 677 supplement, users of this product should know its safe use. 

According to the company, this supplement is safe to take daily. Users should take 4 capsules of this supplement 30 minutes before the training session.

It is also recommended to use this supplement in conjunction with a healthy diet and regular exercise for at least 3 months.

Just like Ibutamoren, this supplement is also safe for stacking. 

IBUTA 677 Procurement Features

If you wish to buy IBUTA 677, it is highly recommended to get it from the official website.

The company, Crazy Bulk, offers many procurement benefits such as the following:

  • Free shipping
  • Buy 2 +1 deals
  • 100% 60-day money-back guarantee

If you subscribe using your email, you can get an additional 20% off on your first IBUTA 677 purchase. 

One great thing about the site is that there is 24/7 chat support.

The agents here can answer your queries and help you find the best deals.


Indeed, Ibutamoren offers many health benefits not just to the muscles but to the skin, bone, immune, and mental health as well.

However, this drug is contraindicated in some patients and it also comes with dangerous side effects.

Because of this, many athletes and bodybuilders look for alternatives.

One of the best legal alternatives for MK-677 is IBUTA by Crazy Bulk.

If you wish to purchase this supplement, it is highly advised to get from the official website to get more deals and other procurement benefits.

Frequently Asked Questions (FAQs)

What are the common side effects of Ibutamoren?

The most common side effects of Ibutamoren include water retention, swelling, joint pain, and reduced insulin sensitivity. 

Can Ibutamoren promote weight loss?

Ibutamoren can help you burn fat and tone your muscles. However, this drug can increase your appetite. When this happens, you might crave more food than usual, and this can lead to weight gain.

Is Ibutamoren legal?

Based on clinical trials, Ibutamoren has shown to be effective in treating patients with growth hormone deficiency. However, this drug is not yet approved by the FDA, and buying it for recreational purposes is illegal.

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