Home Everything Wellness GutConnect 365 Reviews – Is Dr. Vincent Pedre’s Supplement Worth it?

GutConnect 365 Reviews – Is Dr. Vincent Pedre’s Supplement Worth it?

by Charmaine Canlas, RPh

Digestive issues are prevalent problems anyone can experience.

Indigestion or constipation with symptoms of bloating, stomach discomfort, and feeling tired can be bothersome.

Your quality of life is compromised, affecting your mood and productivity. You may have considered taking a supplement but feel hesitant about it.

With so many dietary pills in the market, it can be hard to choose the best for your gut health and digestive health.

The best way to learn about a product is by looking into its ingredients.

One supplement that states to have the best ingredients and doctor-approved formulation is Gut Connect 365.

With health claims to help with a leaky gut and correct your digestive system.

This review will help you understand these ailments and what the supplement Gut Connect 365 truly offers.

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Gut Connect 365 Review – Ingredients, Side Effects, and Customer Reviews

Gut Connect 365

What is Gut Connect 365?

Gut Connect 365 is a dietary supplement made to repair your gut and digestive system.

It boasts its nine ingredient formulation made by Dr. Vincent Pedre.

It comes in powder form dissolved in water and flavored vanilla cinnamon.

Gut Connect 365 Ingredients

Its formulation contains nine superfoods to support its health benefits with other ingredients to aid in flavor and blend.

L-Glutamine has the highest dose at 5000 mg with sufficient research to prove its benefits.

Taking aloe vera extract, however, has health issues that are important to be aware of as a consumer.

Other ingredients that support the blend include natural flavors, stevia leaf extract, and MCT oil powder.

We will further dive into details and the scientific research of every ingredient below.

1) L-Glutamine

It is an amino acid that helps synthesize protein in the body for nutrition. Glutamine is a non-essential amino acid under normal conditions.

So the body abundantly produces it for multiple roles for various organs and cells, including intestinal cells.

However, recent research now defines glutamine as a conditionally essential amino acid.

It means that under stress, heavy exercise, injury, and severe illness, the amount of glutamine in the body drastically drops.

In these conditions, the body depends on glutamine supplementation.

It has made glutamine a popular dietary supplement.

It is the most beneficial and researched ingredient in Gut Connect365. Glutamine is utilized by intestinal, renal, and immune cells in large amounts.

There is evidence to recognize the importance of L-glutamine as an essential dietary supplement.

It helps maintain the levels of glutamine in the body to support mucosal integrity and barrier function. This function of glutamine can decrease intestinal permeability.

These are important for keeping the gut healthy.

It also helps build and maintain muscle mass.

Animal and clinical trials have shown that glutamine deficiency leads to damage in the small intestines.

It also results in an increased risk of infections because of the impairment of immune cells.

A 2017 animal study provides evidence that glutamine can ease constipation by the gut microbiota, which benefits gut health and function.

Other animal trials exhibited the benefits of glutamine in diarrhea by enhancing water and salt intake.

Due to its various roles in the gastrointestinal tract, the demand for glutamine is more than 15g/day.

This demand may not be met in certain conditions, which the body depends on dietary pills.

In combination with N-acetyl cysteine and zinc, it partially repairs the gut.

One of the most recent studies on glutamine in 2021 has shown that it can benefit gut health. It supports the gut microbiome, gut mucosal wall, and by modulating inflammation.

The study also delved into the gut-brain connection.

It states that glutamine supplementation may provide nutritional support in cases of depression.

An optimized gut microbiome can perform its tasks for neuropsychiatric functions efficiently. Glutamine has been intensively studied for its role in the intestine.

But most of these are observational studies, and these health benefits remain to be scrutinized by doctors.

Further research on its mechanism of action and human clinical trials is required.

However, these studies have proven that glutamine supplementation is considered safe.

Always consult with your doctor before taking supplements with L glutamine, as it can have contraindications.

2) Quercetin Dihydrate

It is found in various plants and is rich in antioxidants.

In 2016, a study on pigs evaluated the effects of quercetin.

It resulted in alleviating intestinal injury by decreasing oxidation and inflammation. Another study on quercetin demonstrates an enhanced intestinal barrier function.

Most of the existing research on quercetin is animal trials, and its particular effect on gut health is still lacking.

3) Slippery elm bark

slippery elm bark

It has a long history of use to relieve gastrointestinal diseases, treat diarrhea and decrease inflammation.

As an antioxidant, slippery elm may be effective for treating inflammatory bowel disease.

A study on herbal medicines, including slippery elm, has prebiotic potential and may benefit the gut microbiota.

Researchers also found slippery elm to help control blood sugar levels, which could help with weight loss.

Despite its growing popularity, the research needed to prove its benefits is also still lacking.

4) Organic Marshmallow Root

Marshmallow Root

This ingredient is a herb found in the middle east, commonly prescribed for inflammation and gastritis.

Some studies suggest that organic marshmallow root has soothing properties and coats the stomach wall and esophagus.

However, further research is needed to prove its effects.

5) N-Acetyl Glucosamine

It is a monosaccharide that influences the formation of cell walls, preventing bacteria from getting through.

N-Acetyl glucosamine also has an excellent safety profile.

It has several benefits for skin, joint health and is an anti-inflammatory.

Clinical trials have exhibited its benefits for osteoarthritis.

However, its particular effect on the gut is yet to be studied thoroughly.

6) Licorice Root Extract

Licorice root

Like the other ingredient in GutConnect 365, deglycyrrhizinated licorice root extract is a traditional herbal remedy used for years.

It is a Chinese medicine that has been used to treat conditions like stomach pain.

Deglycyrrhizinated licorice root extract in Ayurveda is often used as a demulcent, mild laxative, and anti-inflammatory.

Some products containing licorice root may relieve digestive symptoms, like alterations in the gut microbiota by prebiotic effect.

However, the role of licorice root and its mechanism is unknown.

It is generally considered safe, but prolonged consumption in large amounts may cause health concerns.

People with high blood pressure, heart, or kidney disease must take caution.

7) Aloe Vera Extract

Aloe Vera

The oral supplementation of aloe vera acts as a mild laxative.

Researchers have studied its benefit for the gut in a clinical trial for patients with irritable bowel syndrome.

The study showed aloe vera to reduce abdominal pain and flatulence in patients with constipation.

However, a 2019 study investigated the adverse effects, drug interactions, and possible toxic and carcinogenic effects.

It is recently classified by the International Agency for Research on Cancer as a carcinogen through animal trials on rats.

Because of the rising popularity of taking aloe vera as a dietary supplement, researchers have concerns about its long-term use.

These findings, however, need further clinical trials to weigh their risks and health benefits.

8) Maitake Mushroom Extract

Maitake Mushroom Extract

The most researched form of Maitake is maitake D-fraction extract.

This extract is made from maitake mushrooms from the mountains of northeastern Japan.

Researchers have evaluated it to affect inflammation and the immune system.

Therefore, the therapeutic effects of Maitake mushroom extract may benefit patients with cancer, autoimmune diseases, and allergy.

Further scientific studies on humans are needed to determine their mechanism of action.

7) Zinc Orotate

Zinc is found to have many health benefits, such as for cold, immune function, and diarrhea.

There are studies on the association between zinc and gastrointestinal (GI) disease.

It describes zinc supplementation to enhance intestinal barrier function and tight junctions.

Zinc deficiency is associated with multiple diseases such as inflammatory bowel disease, celiac disease, diarrhea, and GI cancer.

Zinc supplementation is recommended as safe prevention of gastrointestinal symptoms linked with zinc deficiency.

However, there are known interactions of zinc with other medications.

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  • Reduces Bloating
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Who created GutConnect 365?

Gut Connect 365 is manufactured by the company United Naturals.

However, the website now redirects to a new website.

It markets its products under the new name NatureM.D.

They promote it to be formulated by Dr. Vincent Pedre, M.D. He is a certified medical doctor and chief wellness officer at the company.

His background includes a degree from the University of Miami School of Medicine and a medical director of Pedre Integrative Health.

He promotes eastern and western medicine for patients, appeared on Doctor Oz show, Good Morning America, and wrote a book on gut health.

Gut Connect 365 is described on the website to support healthy gut lining and microbiome, improve nutrient absorption, and boost the immune system.

It focuses on the benefit of GutConnect 365 to treat a leaky gut.

Other claims include an improved mood, fewer digestive problems, better weight management, and better sleep.

The product is stated to be manufactured in certified facilities in the United States and sourced from a combination of eastern herbal traditions and western medical science.

What is Digestive & Gut Health?

Gut health was criticized for the lack of evidence on its influences on overall health.

However, it is increasingly gaining recognition for its role, studies on its effect on the immune system, inflammation, and improved mood.

You can maintain a healthy gut by eating healthy.

But because of the increasing habits in society and life stresses, it becomes challenging to support gut health alone without supplementation.

Gut health is influenced by a condition called “Leaky gut syndrome”, which GutConnect 365 claims to treat.

A compromised intestinal mucosal integrity and breakdown of gastrointestinal mucosal barrier function leads to this condition.

It is associated with injury, joint pain, infection, immunity, radiation, and other types of stress.

An increase in intestinal permeability results in the invasion of allergens, toxins, and pathogens, leading to immunological stress and inflammation.

Glutamine, an ingredient of GutConnect 365 with the highest mg, is considered an essential nutrient for healing the intestinal lining in the gut.

Gut bacteria or gut flora in health are evaluated to be involved in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), obesity, autoimmune disorders and diabetes.

Prebiotics and probiotics are widely used treatments of diseases relating to gut health.

The gut microbiome has a significant influence on IBD development through the regulation of inflammation in the gut.

Gut Connect 365 includes different herbs that have prebiotic effects, which support this finding.

Who the product is not for:

1) Ages under 18 years old

This product is not meant for ages under 18 years old.

If your child is experiencing digestive issues or gastrointestinal disease, consult a pediatrician for a proper treatment meant for minors.

2) Have pre-existing conditions

Some of the ingredients of GutConnect 365 have specific interactions with diseases and medications.

Consult your health care provider to seek medical advice before taking dietary pills.

3) Pregnant or nursing women

Intake of this dietary supplement may have adverse effects on pregnant women.

It may not be safe to use in pregnant or lactating women.

Some of the ingredients may cause congenital disabilities or reproductive harm.

4) Cautious about carcinogens

You will find a warning on the website for an ingredient found in GutConnect 365 that is recognized as a carcinogen.

In the above discussion, we presume it to be aloe vera extract.

The cons of Gut Connect 365

1) Expensive

It is more expensive compared to other supplements on the market.

2) Claims for benefits

Not all of its ingredients have particular benefits for the gut.

Some of the claims found on the website for GutConnect 365 have lacking evidence.

There need to be further studies and human clinical trials to ascertain its efficacy in treating a gastrointestinal disease or a leaky gut.

3) Side effects and warnings

There are certain ingredients mentioned above that may affect individuals with existing diseases.

People with heart or kidney disease may have complications with this product.

It is essential to always consult a healthcare provider before taking any dietary supplement.

A warning for Aloe vera can be found on the website.

 “WARNING: Consuming this product can expose you to chemicals including lead which is known to the State of California to cause cancer and congenital disabilities or other reproductive harm. For more information, go to p65warnings.ca.gov/products/food.“ 

We Recommend...

Leaky Gut Revive®


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  • Reduces Bloating
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  •  Regenerates Gut Cells Faster
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GutConnect 365 Reviews From Customers

Reviews found on Amazon had a mix of opinions.

Some people experienced diarrhea.

This effect may be due to the mild laxative effects of its ingredient.

Others labeled it as a scam for not working, but dietary supplements don’t work for all.

Complaints by customers on the return policy were also expressed.

“I love this! I have been taking for almost 2 weeks and I can feel difference on my stomach. But not only taking this, and keeping bad eating habits.. I have been eating healthier.

More greens less processed foods. I am little more active, I drink more water less sodas, and I’m feeling way better. No constipation anymore. I take in in the morning on an empty stomach with 8oz cup of water on the go on my way to work. Works wonders”

“Have had an array of gut issues for a good portion of my adult life. After cutting out a lot of foods, I still do have some sensitivities that make me bloat or get sick easily (dairy).

But this mixed with another supplement first in the morning in cashew milk.. gives me an insanely different experience during the day. There are a lot of weirdly terrible reviews.. but I have found it extremely helpful and have noticed a significant improvement in my gut.”

The overall rating for GutConnect 365 is 4.1 from 329 customer ratings.

The majority of the reviews gave good ratings.

The Pros of Gut Connect 365

1) Doctor-approved formulation

The website promotes its ingredient for the benefits of Gut Connect 365.

It has ownership for its formulation.

The company states that it is a doctor-approved formulation made by Dr. Vincent Pedre, M.D.

You can find precautions and warnings stated by the company about its product, advising to consult a doctor to provide medical advice.

However, the overall formulation does have some scientific evidence backing up some of its claims.

2) Promotes ingredients

The homepage contains descriptions of the main ingredients found in their products.

It exclaims how the company focuses on obtaining the right ingredients from the best sources found in the world.

The product uses natural flavors and natural stevia extract to make Gut Connect 365 have a pleasant taste.

3) Environmental friendly

It promotes its ingredients as sustainable and eco-friendly.

It is also GMO-free, gluten-free, vegan, and soy-free.

What to watch out for

1) Leaky gut syndrome

They advertise GutConnect 365 to support a leaky gut.

This condition is a controversial topic in science.

A proper diagnosis of it is still under clinical research.

The claim of Gut Connect 365 that it helps repair leaky gut is still a presumption.

However, this dietary pill does have benefits for some symptoms related to digestive health and gastrointestinal diseases.

If you have concerning symptoms you suspect are caused by a particular illness, it is best to consult your doctor to make sure of your condition.

2) Health benefits as a supplement

This product may not work for everyone and may cause side effects for specific individuals.

However, it does not make a dietary pill a scam if it does not work for you.

The awareness of this possibility is vital before purchasing any supplement.

Buying Advice

You can purchase Gut Connect 365 at their new website NatureM.D., which you can find on top of its old website United Naturals.

This practice will help you avoid scams and make sure of the authenticity of the product. It also includes free shipping for every purchase.

They sell Gut Connect 365 in a pack of a single bottle, 3 bottles, or 6 bottles.

A bottle contains 9.9 OZ or 282g of flavored powder formula.

For a better deal, discounts are available for purchasing multiple bottles of Gut Connect 365.

It also offers a 60-day money-back guarantee.

The company allows you to return up to two empty or partially used containers of GutConnect 365.

In conclusion

The safety of Gut Connect 365 will depend on certain conditions.

The company advises you to consult a doctor if you have existing diseases or taking prescription medicines.

United Naturals or NatureM.D. promotes its product transparently, focusing on the ingredients.

It states that doctors thoroughly study the formulation of GutConnect 365.

The overall formulation poses benefits. However, it is essential to be aware of its contraindications and warnings.

Gut Connect 365 contains nine superfood ingredients.

Some of it does provide research for its health claims.

Other herbal remedies found in GutConnect 365 are traditional or ayurvedic medicines used in eastern countries for specific ailments.

The evidence for their efficacy is lacking, and most of them are evaluated through animal trials.

The main ingredient, L-glutamine at 5000 mg, has enough studies to back up its claims.

The positive reviews on GutConnect 365 praised its taste and benefits on digestive problems and better energy levels.

The overall effect of GutConnect 365 for a person will depend individually.

We advise you to ask a health care provider if GutConnect 365 is for you.

A better diet and a healthy lifestyle will also help you experience benefits from this supplement.

Frequently Asked Questions (FAQs) About GutConnect 365

When should I take GutConnect 365?

You can take it once a day before meals, preferably before lunch. Some prefer to take it before breakfast, whichever you prefer.

How do I take Gut Connect 365?

One scoop of the powder is mixed into an 8 oz glass of water and taken once per day. But the suggested starting dosage is half a scoop for the first two weeks.

How long does a bottle last?

A bottle can last for 30 days, with one scoop a day.

Can you take GutConnect 365 with hot water?

It is better to take it with lukewarm water. The nutrients in the formula may degrade and have less benefit from the heat.

Is Gut Connect 365 a scam?

Buy the product from the official website to avoid counterfeit products, but the product itself is a legitimate dietary supplement.

Does GutConnect have contraindications?

Some medicines such as antihypertensives and glutamate blocking drugs may interact with Gut Connect 365. People with heart or kidney disease and severe illness must consult their doctor first.

We Recommend...

Leaky Gut Revive®


  • 10x More Effective Than GutConnect 365
  • Reduces Bloating
  • Promotes Regular Bowel Pattern
  • Restores Gut Lining
  •  Regenerates Gut Cells Faster
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