Best Supplements For Leaky Gut: Probiotics & Vitamins to Heal Leaky Gut Syndrome

Best Leaky Gut supplements

Since you’re on this post, chances are that you or a loved one are affected by the leaky gut syndrome, which many still do not understand is an actual digestive system condition.

It causes gut inflammation, and the intestinal walls also become excessively permeable.

But we are among those who know that it is, and we also understand how much discomfort and inconvenience it brings.

As such, we have prepared a list of the best leaky gut supplements on the market.

These supplements are designed to specifically target leaky gut syndrome and help restore balance to your or your loved one’s gut health and digestive health.

These ten unique leaky gut supplements are formulated primarily with natural ingredients to give you a healthy gut and reduce inflammation.

Our Top Picks

Top 10 Leaky Gut Treatment Supplements of 2021 – Best Pills

1) 1MD GutMD

Dr. David Kahana, a 20-year veteran physician, and gastroenterologist specialist, developed GutMD.

The advanced formula contains four powerful ingredients, l-glutamine, GutGuard, Acacia Fibregum, and HMO CARE4U.

GutMD remains one of the best treatments to maintain gastrointestinal tract integrity by reversing the conditions that lead to a leaky gut.


  • Formulated with clinically studied ingredients.
  • Affordable
  • It is preservative-free.
  • Offers multiple discounts
  • Contains the gut-protecting compound GutGard derived from licorice root
  • Discounts are available through the subscription box package pricing options.


  • The manufacturers suggest that it may take a minimum of three months to see full results.

How Does GutMD Work?

The combined effect of the four key ingredients makes GutMD a potent supplement to help your body repair leaky gut. Let’s explore how each ingredient helps:

1) L-Glutamine

Although your body produces l-glutamine amino acids, you can develop a deficiency, so taking additional amounts may see you reaping health benefits like a faster intestinal wall recovery rate.

Your intestinal wall regenerates over 48 hours, and clinical studies prove l-glutamine’s effectiveness in speeding up wall renewal while reducing the permeability of the intestinal wall junctions.

A less porous gut limits the penetration of the gut wall by undesirable agents, including viruses, fungi, and antigens, while allowing essential nutrients to go through, promoting good health and a strong immune system.

2) GutGard®

Licorice root-based GutGard® helps protect the gut from bloating, heartburn, indigestion, gas, upset stomach, and Helicobacter Pylori (H.Pylori). It also supports probiotic growth.

3) Acacia Fibregum

Acacia Fibregum is a prebiotic, containing living microorganisms like yeast and bacteria and creating conditions necessary for more healthy gut bacteria to grow.

You gain double the benefits of healthy intestinal microbiome metabolism that rejuvenates the intestinal walls and epithelial lining and weight management from the acacia gum probiotic.


Human identical oligosaccharides (HMOs) are produced from natural ingredients.

HMOs fight toxins and enable your body to maintain a healthy bacterial balance.

Why GutMD Leaky Gut Supplement Made it onto Our List

GutMD manufacturers pride themselves on taking a comprehensive approach to gut wall health, improving digestive tract health, and combating leaky gut syndrome.

Its powerful formulation is designed to reduce intestinal permeability and aid with other digestive issues, as testified by past and current customers.

Scientific evidence suggests that GutMD also has the potential to:

  • boost your immune system
  • increase movement in the intestinal tract
  •  improve your bodies absorption

2) Amy Myers Leaky Gut Revive

Physicians developed Leaky Gut Revive®, a natural blend of nutrients containing pharmaceutical-grade l-glutamine and five other key ingredients.

This leaky gut supplement provides relief and quickly repairs damaged and leaky gut lining.

The powerful therapeutic botanical combination in Leaky Gut Revive® helps to remedy the root causes of leaky gut.

In so doing promotes improved digestion, reduces bloating, enhances gut-lining repairs, and better wellness and appearance overall for users.


  • The powder form works better for people who dislike tablets and pills.
  • Does not contain gluten or wheat.
  • Safe for dairy-free diets.
  • GMO-free.
  • The powder can be mixed into beverages.
  • Almost tasteless.
  • It can be had night or day.
  • Affordable
  • It can be taken with or without food.


  • Some persons may find the taste slightly unpleasant.
  • A few customers reported diarrhea.

How Does Leaky Gut Revive Work?

To promote leaky gut health, the product works through a three-step process to fix a leaky gut that occurs when the naturally semi-permeable gut lining that renews every 48 hours becomes excessively porous due to l-glutamine deficiency.

Step 1

Leaky Gut Revive contains 3000 mg of l-glutamine per serving, this non-essential amino acid your body naturally synthesizes and supports intestinal health at the cellular level.

Amino Acids are the building blocks of proteins, and l-glutamine helps speed up the renewal of leaky gut lining, strengthening the intestinal barriers.

The reinforced leaky gut wall prevents antigens such as bacteria, viruses, fungi, and potentially allergenic or inflammatory proteins from contaminating your bloodstream and lymph.

Step 2

Another Leaky Gut Revive ingredient, Larch arabinogalactan, is a North American Larch Tree extract.

It is a probiotic that contains living microorganisms and creates conditions for healthy bacteria to ferment and activate the leaky gut healing process.

The fermentation also produces powerful immune function boosters called butyrate fatty acids.


The final Step is mucous membrane repair acceleration using slippery elm root and marshmallow root that assists the mucous membranes to produce more mucus to coat the gastrointestinal tract.

This small but significant feature strengthens the intestinal barrier and reduces leaky gut risks.

Why the Leaky Gut Revive Supplement Made it onto Our List

Considering that one of the best recovery modalities is to go is all-natural, and this physician-formulated 6 in 1 blend of nutrients is that and more, we had to include it in our list.

With its therapeutic botanicals, Revive can quickly soothe and repair your leaky gut providing you with a healthier digestive tract by:

  • reducing belly bloating
  • improving digestion
  • repairing the leaky gut lining

3) Elm & Rye Probiotic

Elm and Rye Probiotics

Elm & Rye Probiotic may just be one of the best leaky gut supplements available.

It contains one very potent active ingredient; lactobacillus acidophilus.

This ingredient helps destroy bad bacteria that may escape from your gut into your bloodstream and lymph to cause autoimmune diseases. It is also known to strengthen your immune system.

This leaky gut supplement also delivers the probiotics to your gut using gelatin, vegetable magnesium stearate, and ditab-filled capsules.

These inactive ingredients play a vital role in ensuring that the active bacteria, lactobacillus acidophilus, gets delivered safely to your digestive tract.


  • Contains no preservatives.
  • Does not contain gluten or wheat.
  • Safe for dairy-free diets.
  • GMO-free.
  • Soy-free
  • Affordable


  • Only offers one strain of probiotic.

How Does Elm & Rye Probiotic Work?

Among the leaky gut supplements available, Elm & Rye’s sails alongside those that deliver a single-strain probiotic supplement, introducing lactobacillus acidophilus bacteria to you.

When multiplied, this active ingredient naturally occurs in your intestines and offers significant health benefits.

  • Derived from the Lactobacillus bacteria genus, it is essential in promoting good gut health for you and your family. The probiotic promotes the increased growth of good bacteria and produces lactic acid and hydrogen peroxide from sugars. The hydrogen peroxide and lactic acid limit undesirable bacteria growth in the intestines, limiting leaky gut effects like the seepage of bad bacteria from your digestive tract into your bloodstream and lymphatic system.
  • When combined with other antibiotics, Lactobacillus acidophilus bacteria probiotic is known to reduce bacteria-induced diarrhea, bloating, and cramps. You will experience relief from symptoms that may include life-threatening colon inflammation (C. difficile infection).
  • The emphasis Elm & Rye places on creating a safe and healthy product are observed in the strategic use of gelatin, vegetable magnesium stearate, and ditab in manufacturing probiotic capsules. They intentionally avoided using any preservatives that can cause harmful side effects.
  • FDA approved Magnesium stearate is an inactive ingredient and additive used to prevent the capsules from sticking to each other, ensuring quality and individual daily usage of each capsule.
  • Ditab is an inactive ingredient consisting of white, tasteless, and odorless granules used as a filler to increase capsule sizes for practical daily usage.
  • Natural animal protein gelatin in the capsules assists with the delivery of timed and measured probiotic quantities to your body. It protects the capsule ingredients from oxidation, light, moisture, and contaminants. Soluble gelatin dissolves in your body at normal body temperatures.

Why Elm & Rye Probiotic Made it onto Our List

Scientific evidence suggests that probiotics are the ideal multi-purpose option for gut health.

So why not include it on this list, right? Also, Elm & Rye Probiotic may:

  • improve your digestion of lactose
  • alleviate other digestive issues like bloating, abdominal pain, gas, diarrhea, and constipation
  • assist with carbohydrate digestion and the production of several vitamins.

4) Colon Detox Plus

Colon Detox Plus contains eight primary natural ingredients and extracts that support colon cleansing and boost your detox activities.

This leaky gut supplement’s formulation includes psyllium, lactobacillus acidophilus, rhubarb, gentian, aloe vera, cascara sagrada, buckthorn, and alfalfa leaf.

Colon Detox Plus helps clear your intestinal tract of toxin-loaded waste, which prevents replenishing the intestinal walls, leading to conditions like leaky gut, irritable bowel syndrome, etc.

Optimized absorption of healthy nutrients into your bloodstream is also restricted by the waste buildup that contains bacteria, fungus, antigens, and other unwanted substances seeping into your bloodstream and lymphatic system.


  • Formulated with high-quality ingredients.
  • Designed to be a 15-day course.
  • Very affordable
  • Recommended by several clinics, including Mayo Clinic and Medline.
  • Fast-acting


  • It may cause cramping abdominal pain.

How Does Colon Detox Plus Work?

Unhealthy diets and inactivity disrupt your digestive system making it difficult to obtain optimum health.

VitaPost Colon Detox Plus clears the undesirable buildup that gives you that bloated look and feels while restricting the absorption of essential vitamins and minerals.

Let’s examine how each ingredient improves your gut health.

1) Psyllium

Psyllium (Plantago psyllium) is a plant fiber often used to support GI health. When ingested, it acts as a prebiotic, meaning probiotic bacteria will feed on it. Psyllium also supports gut hydration.

2) Lactobacillus Acidophilus

Lactobacillus Acidophilus probiotic is a good bacteria that occur naturally in your intestinal tract. It helps boost our immune system and destroys bad bacteria like H. pylori that causes harm when it seeps into the bloodstream.

3) Rhubarb

Rhubarb boosts gastrointestinal health and the peristaltic motility of food. It also supports pancreatic and intestinal health.

4) Gentian

Gentian is an herb with antioxidant properties that supports the digestive system and your gastrointestinal health.

5) Aloe Vera

Aloe vera latex naturally soothes discomfort brought on by frequent bowel movements. Aloe vera latex improves digestive organs’ natural functions and movements while supporting stool consistency.

6) Cascara Sagrada

Cascara herb supports digestive functions as a natural stimulant laxative causing bowel muscle contractions.

7) Buckthorn 

Buckthorn bark, from the Alder buckthorn plant, is activated to cause bowel movements when dried and heated. It is also great for hemorrhoids

8) Alfalfa Leaf

Alfalfa keeps your digestive system healthy, and research has confirmed the link between alfalfa leaf extract and the healing of peptic ulcers inside the stomach lining and small intestines. It also supports your immune system.

Why Colon Detox Plus Made it onto Our List

Colon Detox Plus comes highly recommended by experts for its use of blond psyllium, which can relieve constipation and improve stool consistency.

Additionally, it can:

  • help you clear waste buildup in the digestive tract
  • promote overall health and wellness
  • help you feel lighter and relieved with the removal of waste and bloating

5) Gundry MD Total Restore


Noted surgeon and author Dr. Steven Gundry created Gundry MD Total Restore as a leaky gut supplement to protect against the harmful effects of leaky gut.

These leaky gut supplement capsules contain over 20 active ingredients that contribute to improving the health of the digestive system allowing patients to enjoy the benefits and wellness associated with having a less permeable gut.

Some of the ingredients found in the product include l-glutamine, zinc, magnesium beta-hydroxybutyrate, grape seed extract, n-acetyl-d-glucosamine, black pepper licorice roots, and rhizome powder, clove bud powder, maitake mushroom fruit extract, marshmallow root powder, and cinnamon bark powder among others.


  • Affordable
  • Fast-acting
  • 90-day moneyback guarantee


  • Contains crustacean crabs and shrimp, and as such, it is not suitable for people with food allergies.
  • 3-capsule serving size

How Does Gundry MD Total Restore Work?

A healthy gut is semi-permeable, allowing healthy nutrients into the bloodstream while restricting harmful viruses, bacteria, fungi, and antigens.

Gundry MD Total Restore contains the non-essential amino-acid l-glutamine, essential for speeding up the regeneration of a more resilient or less previous gut lining at the cellular level.

The supplement works by achieving four goals in your body.

We will take a closer look at these goals and explain how the ingredients assist you in achieving them.

Combats out-of-control food cravings
  • Cinnamon bark, a natural appetite suppressant found in Gundry MD Total Restore, helps you avoid those foods that cause inflammation and disrupt gut health. Appetite suppression also helps reduce the pile-up of waste that restricts absorption in your intestine.
Help fight achy muscles and joints
  • The ingredient Zinc is an anti-inflammatory relieving joint and muscle pain. It helps boost immunity.
Reduces gas, bloating, diarrhea, and constipation
  • Ingredients licorice roots and rhizome powder relieve gastroesophageal reflux disease (GERD) symptoms like acid reflux, indigestion, and heartburn. Clove bud powder possesses compounds helpful in relaxing the GI tract lining, relieving common digestive troubles like vomiting, diarrhea, flatulence, and stomach aches.
Boosts energy
  • Magnesium beta-hydroxybutyrate is an energy booster, but you will also feel more energized when your immune system is in top shape. N-acetyl-d-glucosamine destroys the biofilm that protects bacteria like E. Coli while maitake mushroom fruit extract helps to enhance your immunity.

6) L-glutamine


Glutamine is an amino acid that plays a vital role in immune system health.

Even though our bodies produce glutamine naturally, we may require additional supplementation from time to time.

That’s where l-glutamine comes in.

Numerous l-glutamine supplements on the market will help restore gut flora and leaky combat gut naturally.

L-glutamine has proven to be one of the best leaky gut supplements in remedying intestinal inflammation.

Most leaky gut supplements are formulated with l-glutamine since it is one of the most highly recognized leaky gut health supplements.

It is also the most abundant amino acid in the blood and other body fluids.

Glutamine is an essential source of energy for intestinal and immune system cells.

To prevent leaky gut and improve gut health, it aids in maintaining the barrier between the inside of the intestines and the rest of the body.


  • L-glutamine supplements are completely natural.
  • L-glutamine is laboratory tested and proven effective against leaky gut syndrome.
  • Affordable
  • Available in powder and capsules.
  • Easy-to-mix powder
  • Free of artificial flavors, colors, and sweeteners.


  • The taste may be unpleasant for some people.

Why L-glutamine Made it onto Our List

As a leaky gut supplement, l-glutamine remedies and prevents leaky gut syndrome from restoring and maintaining your gut health.

We appreciate the essential role it plays in immunity and energy production. Additionally, l-glutamine may:

  • facilitate the normal growth and maintenance of the cells in the intestine
  • provide fuel for immune cells

7) Gundry MD Bio Complete 3

Bio Complete 3 is another fantastic product among leaky gut supplements.

It is created by Dr. Steven Gundry, MD, who was earlier established as one of the world’s most celebrated pediatric heart surgeons and a best-selling author.

Bio Complete 3 is said to be marketed as the ideal leaky gut product, formulated with prebiotic, probiotic, and post-biotic ingredients.

Many have testified that Bio Complete 3 has a unique formulation that makes it one of the market’s more desirable leaky gut supplements.

It may independently provide optimal relief from leaky gut symptoms to enhance gut health and restore digestive enzymes and digestive health.

Healing leaky gut syndrome is no easy task; we recommend only the most efficient leaky gut supplements that have been proven to restore digestive health, repair the intestinal lining, and facilitate a healthy intestinal barrier.

Bio Complete 3’s blend of powerful ingredients is formulated to specifically heal leaky gut and improve the presence of healthy bacteria while reducing intestinal permeability and other digestive issues.

Let’s look at how those prebiotic, probiotic, and post-biotic ingredients can help heal leaky gut.

  • Prebiotics are a source of food for the healthy bacteria within your gut. Good gut bacteria are instrumental in the digestive process and also aid with removing harmful bacteria.
  • Probiotics provide the body with billions of healthy live bacteria. These include live beneficial bacteria and or yeasts that naturally live in the body.
  • Postbiotics are the newest member of the biotics family. Postbiotics are compounds created when the healthy bacteria in your gut break down prebiotic food in the colon. Also, postbiotics assist with protecting the lining in the gut to prevent a leaky gut, increase nutrient absorption, and support colon health.


  • Affordable
  • Package savings are available.
  • No added sugars, lectins, or artificial sweeteners.
  • Ingredients for this formula were chosen based on clinical results.


  • 4-capsule serving size with a 30-capsule serving per container.

How Does Gundry MD Bio Complete 3 Work?

Simply and consistently taking two small capsules twice daily before a meal, your body will begin to break down the supplement almost immediately into energy.

Its formulation of tributyrin, Sunfiber, bacillus coagulans, and other ingredients work collaboratively to combat brain fog, decrease intestinal permeability and improve nutrient absorption.

1) Tributyrin 

To be exact, Tributyrin (Butyrate) is essential for proper functioning the gut, the small intestine, and colon cells.

2) Sunfiber

Sunfiber is known for relieving the symptoms of constipation and diarrhea, optimizing gut health, and ensuring stool content is healthy.

3) Bacillus Coagulans

Bacillus coagulans is a probiotic used to improve immune function and treat diarrhea and constipation.

Why Gundry MD Bio Complete 3 Leaky Gut Supplement Made it onto Our List

Bio Complete 3 is deserving of a spot on our list as it not only promotes a healthy intestinal mucosal lining and overall gut health by keeping the toxins from leaking into your system, but it may also:

  • supercharge your energy level
  • induce an incredible ‘slimming effect,’
  • improve bowel movements
  • enhance mental clarity

8) Nature’s Bounty Zinc

Natur's bounty zinc

The nutrient zinc plays a vital role in many bodily functions.

So Nature’s Bounty has aimed to provide this highly essential supplement to us conveniently and affordably.

Zinc is not produced or stored by the body, so we must take daily supplements of this essential nutrient through food and other means.

In addition to improving immune function, zinc can aid in growth and development, improve wound healing, and help people with gastrointestinal issues like Crohn’s disease.

Nature’s Bounty is a reputed veteran in supplement provision, and their Zinc is clinically tested and formulated with the purest ingredients to support immune function and antioxidant health.

Nature’s Bounty Zinc includes Zinc, Gluconate, Vegetable Cellulose, and Dicalcium Phosphate.

Zinc Gluconate is used to help with immune health and is also used to treat or prevent vitamin deficiency due to poor diet, certain illnesses, or during pregnancy.

Vegetable cellulose is a natural dietary fiber that keeps the lower digestive system in optimal health.

Dicalcium Phosphate aids in enhancing fiber digestion, which in turn helps to promote overall gut health.


  • Manufactured by a 50-year veteran
  • GMO-Free
  • Gluten-Free
  • Validated by clinical research
  • Undergoes numerous quality tests


  • It may not be ideal for pregnant or lactating women
  • May cause nausea
  • It may be hard to swallow

How Does Nature’s Bounty Zinc Work?

Nature’s Bounty Zinc is created with just the right ingredients to contribute to solving several digestive issues and support immune health and the gut microbiome.

Studies have evidenced that zinc acts as one of the most efficient leaky gut supplements manufactured, as it even has the potential to aid in the recovery of patients affected by Crohn’s disease.

The ingredient content of Zinc Gluconate, Vegetable Cellulose, and Dicalcium Phosphate complement each other to formulate the ideal zinc supplement that will adjust certain aspects within the intestinal wall to reduce permeability caused by the leaky gut syndrome.

Why Nature’s Bounty Zinc Leaky Gut Supplement Made it onto Our List

Because of its natural propensity to promote a healthy immune system, we had to add it to our list.

However, there are several other reasons we are impressed with this supplement, some of which include the following:

  • enhancing antioxidant health
  • improving skin health
  • improve metabolism

9) Doctor-Recommended Berberine Plus

Doctor Recommended barberine

Berberine has proved to be a multi-purpose supplement that does much more than aid with leaky gut health.

This leaky gut supplement is made with only one main ingredient Berberine HCI and vegetable cellulose capsules.

Doctor Recommended promises pure, safe, and high-quality products. This Berberine Plus’ formula is specially designed by medical professionals after much research and testing.


  • Affordable
  • All Natural, Free of Soy, Gluten, Milk, Egg, Wheat, GMOs, Peanuts, Sweeteners, Shellfish & Sugar.
  • Trusted Brand! No-Risk – 100% Satisfaction Guarantee (refund guaranteed).
  • Third-party tested
  • 1200 Mg pure Berberine


  • It may be hard to swallow
  • It may cause abdominal cramping
  • Has a strong taste

Why Berberine PlusMade it onto Our List

Aside from the over 7000 raving reviews posted to Amazon by verified customers hailing this supplement’s potency and efficacy, we had to add this Berberine supplement to our list.

Additionally, with the company’s commitment to transparency and delivering the highest quality products, it gives rise to the production of ultra-pure Berberine HcL powder that may:

  • lower blood sugar
  • support immune function
  • gastrointestinal support
  • promote weight loss
  • improve cardiovascular heart health

10) HUM Flatter Me™

HUM Flatter Me

HUM Flatter Me™ is a patented blend of eighteen enzymes to support a flatter stomach, promote digestive health, and a healthy gut lining.

Its formulation is developed based on the results of clinical research.

Consequently, it is designed to support all major phases of nutrient digestion to promote gut health and treat leaky gut in those affected or at risk.

While many leaky gut supplements focus on the intestine only, HUM Flatter Me™ also targets abdominal fat.


  • Formulation is research-based
  • Affordable
  • Vegan
  • Gluten-Free
  • Parabens and Phthalates- free
  • Clean at Sephora badge
  • Non-GMO and soy-free


  • Flavorless

Why HUM Flatter Me™ Leaky Gut Supplement Made it onto Our List

Among the eighteen amazing ingredients in this leaky gut supplement are ginger, fennel, and peppermint, which help diminish bloating and calm digestion.

In combination with these benefits, HUM Flatter Me™ may also:

  • break down fiber
  • break down the milk sugar and processed foods
  • break down carbs
  • improve nutrient absorption

Many leaky gut supplements work better than most gut health supplements currently on the market to reduce stomach acid production, combat inflammatory bowel disease, and support gut health overall.

Leaky gut issues are no joke and must be cared for immediately since if the leaky gut syndrome is left untreated, it can become chronic and lead to many digestive disorders.

We highly recommend this list of leaky gut supplements.

Healing leaky gut should be a priority as soon as you identify its symptoms or get diagnosed with it.

We hope this list will add value to your search for the ideal supplement to remedy your leaky gut syndrome.