Instaflex Joint Support Reviews – Side Effects, Ingredients, & More…

Instaflex Advanced reviews

Welcome to my comprehensive review of Instaflex Advanced…

Instaflex is one of the leading joint support supplements today after Zenith Labs® Joint N-11.

It is marketed as a glucosamine-and-chondroitin-free joint health supplement claimed to help reduce knee discomfort and improve joint function.

Notable studies have found that glucosamine and chondroitin supplements can improve joint pain and slow down the progression of osteoarthritis symptoms.

Many supplements for joint health often combine glucosamine and chondroitin with other beneficial ingredients.

Instaflex Advanced formulators claim that their joint pain formula is better than supplements containing glucosamine or chondroitin.

Solid scientific evidence supports the key ingredients used in the Instaflex Advanced formula.

But is Instaflex Advanced Joint Support the best relief supplement on the market?

And, how do customer reviews rank Instaflex Advanced based on observable joint care benefits?

This Instaflex Advanced review covers everything you need to know about joint care using Instaflex to help you decide if it is the right joint solution.

Our Recommendation

Joint N-11After a series of tests, we believe Zenith Labs® Joint N-11 is the best joint supplement on the market.

Here’s why:

  • Joint N-11 is 10x More Effective Than Instaflex Advanced
  • It optimizes your joints for flexibility, comfort, and long-range health
  • Supports joint lubrication and shock absorption
  • Recommended by Medical Experts

So make sure to check it out. It might just be the best money you’ll spend in 2024.

Instaflex Advanced Review – Is it worth it?

Instaflex advanced

What Is Instaflex Advanced 

Instaflex Advanced is part of a family of wellness and lifestyle brands designed by Dr. David L. Katz.

David Katz MD is a world-renowned American medical physician and the founding director of the Yale Prevention Research Center.

Dr. David Katz is also a respected nutritional researcher known for his holistic approach to weight management, optimal joint health, and overall well-being.

Dr. Katz’s revised Instaflex Advanced Joint formula packs potent natural ingredients backed by ample scientific research.

Other Instaflex wellness formulas may provide extra support for the musculoskeletal system.

Here’s a quick overview of Dr. Katz’s other wellness supplements that may complement or supplement the Advanced Joint Support formula by Instaflex:

  • Instaflex Super Turmeric: Harnesses the powerful potency of Turmeric Curcumin with Bioperine® included for bioavailability.
  • Instaflex Bone Support: Boosts bone strength and aids natural bone repair and development.
  • Instaflex Muscle Support: Works for quick muscle recovery and helps alleviate soreness and cramping.
  • Instaflex Vegetarian Joint Support: a wholly vegetarian joint relief supplement.

Each of these supplements stands its merit and may cater to a targeted group needing reliable joint relief options.

Instaflex Advanced may be Dr. David Katz’s best joint care formula yet.

It promises to provide joint relief in just 7-days after taking one pill consistently daily.

Scientific research supports these claims.

How Does Instaflex Work for Joint Pain Relief?

Instaflex is designed to be a complete joint health supplement.

It employs a two-factor approach to provide joint pain relief.

With a formula that captures the proven potency of the natural ingredients in its joint relief formula, Instaflex combats joint discomfort by:

  • Reducing joint inflammation on the site of pain, and
  • Rebuilding and hydrating connective tissues are found in the joint.

Rather than simply mask joint pain, the Instaflex formula is packed with antioxidants, analgesics, and anti-arthritic compounds, which work to deliver relief right at the site of inflammation.

Along with its lineup of fast-acting pain-relieving stack, Instaflex includes humectants and collagens, which work to keep the joint cartilage moisturized, elastic, and flexible.

Instaflex Advanced also adds a superior bioenhancer in its formula to help increase the presence and bio-efficacy of its other active ingredients.

Overall, Instaflex seems to have what it takes to deal with joint discomfort in the short term and promote better joint function over the long term.

To achieve the above-mentioned therapeutic effects, Instaflex formulators selected natural ingredients tested across multiple scientific studies for their powerful potency.

Here’s a quick look at the dosages of each ingredient:

  • Turmeric (rhizome)(standardized to min 95% curcuminoids) – 200 mg
  • Resveratrol (from Polygonum cuspidatum root extract) – 100 mg
  • Apresflex®-Boswellia serrata Extract (resin) – 100 mg
  • UC-II® (10 mg total collagen, 3 mg undenatured type II collagen) -40 mg
  • Hyaluronic Acid (HA) (min 89%) – 5 mg
  • Bioperine®-Black Pepper Extract (BPE) (fruit) (standardized to min 95% piperine) – 5mg

The following section will examine the science behind Instaflex Advanced ingredients.

The evaluation will also probe whether these ingredients are provided in the exact dosage used in clinical trials.

Instaflex Advanced Ingredients: Research-Based Evaluation

Instaflex Joint Support formula contains six primary ingredients.

A quick look into the existing research on Instaflex ingredients provides valuable information to customers interested in the evidence supporting the product’s proposed benefits.

You will be surprised by the number of health supplements on sale that lacks sufficient (if any) research to back their safety and efficiency.

Instaflex Advanced formulators make available a ton of research backing the potency of their chosen ingredients.

They also subjected their product to several clinical trials, producing promising results for alleviating joint pain in specific patient populations.

A 2013 randomized, double-blind, placebo-controlled study on 110 individuals with a history of osteoarthritis symptoms showed that Instaflex Advanced was twice as effective in alleviating joint pain and stiffness compared to a placebo containing magnesium stearate.

A more recent study operated by Appalachian State University using a randomized, double-blinded, placebo-controlled research design assessed the effectiveness of Instaflex Advanced on knee discomfort in healthy volunteers.

The 2017 study results showed that those taking Instaflex Advanced reported feeling less pain in the knee compared to those randomized to a placebo.

Scientific evidence detailing the potency of the product’s constituent ingredients is just as impressive.

Here is what we found out.

1) Turmeric Extract (95% curcuminoids)


Derived from the root of Curcuma longa, turmeric has gained a credible reputation in joint health due to increasing research studies supporting its pain-relieving effects.

Commonly used as a spice in Asiatic delicacies, turmeric today feature dozens of joint supplements for its well-recognized abilities to reduce inflammation and pain fast.

Its proposed anti-inflammatory properties are attributed to a group of compounds called curcuminoids, which turmeric plants produce.

A systematic review of available research articles and clinical trials on turmeric’s anti-inflammatory agents confirmed that curcumin effectively improved joint stiffness, swelling, and pain more than the placebo.

Studies have suggested that turmeric and curcumin may be as effective as pharmaceuticals (ibuprofen and diclofenac) for reducing joint pain.

A more recent but small 2020 study measured the therapeutic efficacy of Curcuma longa extract (CL) for knee osteoarthritis symptoms scaled by visual analog scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).

The study also measured the effectiveness of CL on diagnosed effusion–synovitis, inflammation of the joint lining, observed by magnetic resonance imaging (MRI).

The study concluded that Curcuma longa extracts improved knee pain. There was no significant change in the cartilage composition of participants diagnosed with effusion–synovitis.

While solid evidence supports the use of turmeric and curcumin for joint relief, official consensus on the effective doses is lacking.

Most studies have used doses of 500mg turmeric extract (typically containing 95% curcumin) for osteoarthritis.

Instaflex Advanced contains 200mg of Turmeric extract, which may align with the World Health Organization (WHO) recommended dose of 1.4mg per pound of body weight.

2) Resveratrol (Polygonum cuspidatum root extract)

The dried root of Polygonum cuspidatum has been used for centuries in Japan and China as traditional herbal medicine.

Its extensive use in traditional Asian medicine has been attributed to the plant’s abundance of a potent antioxidant known as Resveratrol.

Extract from Polygonum cuspidatum root has been found to contain the most bioavailable form of the plant-derived antioxidant called polyphenolic antioxidant trans-resveratrol.

Much of what is known about resveratrol’s beneficial properties is derived from animal studies.

Still, few research studies on human subjects have demonstrated that resveratrol may have wide-ranging effects on human health.

Resveratrol has been studied separately for its beneficial action against free radicals to relieve oxidative stress in both animal models and human subjects.

These studies found that resveratrol may ease joint pain and prevent cartilage degradation.

A 2018 randomized multi-center study involving 11O knee osteoarthritis patients found that resveratrol, when used as a supportive “add-on” to meloxicam (Mlx), significantly improved pain and knee function compared with Mlx alone.

While resveratrol is a potent antioxidant, it may produce superior results for pain and inflammatory biomarkers when co-administered with other medications proven for joint care.

Instaflex Advanced includes 100 mg of resveratrol in its formula, which may be enough to produce results safely.

3) AprèsFlex – Boswellia Serrata Extract

Boswellia Serrata Resin

Also known as Indian frankincense, Boswellia is a botanical medicine from the Boswellia serrata tree, traditionally used in Afro-Asiatic countries to treat chronic inflammatory illnesses.

The resinous exudate or extract obtained from Boswellia serrata features in a patented botanical supplement known as AprèsFlex®.

Modern research has confirmed the gum-resin extract of Boswellia serrata helps reduce inflammation.

The resinous extract contains powerful boswellic acids, which have been examined to inhibit a pro-inflammatory enzyme called 5-lipoxygenase.

Clinical studies with 100mg AprèsFlex have demonstrated the ingredient’s ability to provide joint comfort and improve flexibility in less than a week.

Instaflex is advertised to provide “significant relief in as little as seven days” because it contains the patented form of Boswellia from AprèsFlex.

4) UC-II ® (25% collagen)

Undenatured type II collagen (UC-II) is a collagen ingredient commonly used in joint supplements.

Collagen is the primary structural protein of amino acids, accounting for about one-third of the body’s protein composition.

Type II Collagen is the key component in joint cartilage and other connective tissues. UC-ii® is a patented type ii collagen ingredient derived from chicken sternum cartilage.

As a nutritional supplement, UC-ii aids in the healthy construction of joint cartilage, reducing collagen degradation, and improving joint flexibility.

Studies have tested UC-II ingredients for efficacy in treating rheumatoid arthritis, osteoarthritis, and related noninflammatory joint diseases.

Several studies have shown UC-II to be significantly better than the combination of glucosamine (1500mg) and chondroitin (1200mg) in joint care.

Studies typically used doses of 40mg effectively, similar to what is present in the Instaflex Advanced joint formula.

5) Hyaluronic Acid (89%)

Hyaluronic Acid is naturally produced in the body and is abundant in the skin, hair, eyes, and joint connective tissues.

It is an important humectant (water-loving) ingredient gaining popularity among joint supplement formulators.

Hyaluronic Acid supplements have been found to promote hydration, flexibility, and elasticity in the joints.

In so doing, Hyaluronic Acid supplementation may improve healthy joint function and promote cartilage, tendon, and ligament health.

While Hyaluronic Acid may not directly address joint pain and inflammation, ample research study has shown that it improves the symptoms of knee osteoarthritis.

A 2012 randomized, double-blind, placebo-controlled trial on 60 osteoarthritic patients found that 200mg oral hyaluronic acid taken once daily for 12 months was safe and effective for alleviating pain in or around the knee.

Dosages of 80mg have also been shown to be effective for osteoarthritic knee pain in overweight patients.

Instaflex uses a much less dose of 5mg hyaluronic acid (HA) which may be safe and effective.

6) BioPerine® – Black Pepper Extract

Black Pepper

The extract from black pepper fruit is used in most supplements because it has been found in clinical studies to aid the bioavailability of other ingredients.

Black paper has been observed to contain a molecule called piperine which has been found to inhibit drug-metabolizing enzymes.

Its inhibitory effect is particularly useful for supplements like Instaflex Advanced, which contains curcumin.

In addition to its bio-enhancing effects, piperine in Bioperine® may present antioxidant and anti-inflammatory effects.

However, it is unclear whether the dose of 5mg Bioperine- black pepper extract may limit the inflammatory response.

Instaflex Advanced Safety & Side Effects

Instaflex displays the safety, quality, and potency testing seal from the independent third-party authority, ConsumerLab.

It is also worth mentioning that Instaflex Advanced is manufactured in an FDA-approved facility guaranteeing Good Manufacturing Practices (GMP).

Generally speaking, natural ingredients in dietary supplements like Instaflex Advanced are mostly safe or may present only mild reactions without any adverse effects.

Digestive tract disturbances are perhaps the most common side effects, with many taking nutritional supplements.

Allergic reactions may also present in users sensitive to common ingredients used in joint supplement formulation.

Instaflex Advanced excludes two joint supplement super ingredients (glucosamine and chondroitin) to make it safe for anyone with a true shellfish allergy.

However, research has shown that joint glucosamine is derived from the shells of shellfish, which may not contain clinically relevant levels of allergy-triggering antigens reported in the flesh of the shellfish.

As research results conflict as to whether glucosamine may be safe for users with shellfish allergies, we recommend consulting a healthcare provider to provide proper medical advice.

Anyone experiencing a serious medical condition after taking dietary supplements should seek local emergency services immediately.

Instaflex Customer Reviews

For the most part, users have rated this product highly.

Most customers reported experiencing relief faster after using the supplement compared to other joint formulas they tried prior.

Negative customer reviews are mostly confined to price issues and no relief within seven days as advertised. A few users reported experiencing mild side effects after taking the supplement.

We highlighted a few customer reviews from actual buyers.

I have tried so many products to alleviate knee pain only to be disappointed time and time again.

 I am now an Instaflex customer, and I have told several of my friends and family members about the product… and they can’t wait to try it…I told them not everything works for everybody but this product is surely worth a try.

I give Instaflex 4 stars because it helps some but not all the way. I think the only operative ingredient is the UC-II, since I was already taking most of the other ingredients. BTW I did not stop taking glucosamine and chondroitin. – Donangelo

I can say that Instaflex has almost restored my leg flexibility and I am now starting on my second thirty-day bottle and believe this will restore full use of my left knee completely and I will certainly continue to use Instaflex in the future.

Quick Overview

Instaflex is easily the best glucosamine-free joint health supplement on the market.

Formulators used natural ingredients scientifically tested for pain and inflammation-reducing efficiency.

Besides easing joint pain, the Instaflex Advanced Joint Support formula promotes joint cartilage health and protects against future wear and tear.

Some ingredients were included for their absorption-promoting effects, soothing stiff joints, and enhancing joint mobility within 7 days.


  • Doctor-formulated; Research-backed
  • Proven pain-relieving formula
  • Supports ligaments, tendons, and cartilage
  • Optimizes joints for flexibility
  • Prevents joint wear & tear
  • Free of allergens like shellfish


  • Premium joint supplement – may be costly

Insider Tips: Instaflex Advanced Cost & Where to Buy

Instaflex Advanced is a premium joint supplement, but there are more costly options still.

You can buy Instaflex Advanced directly from the manufacturer’s official website or through trusted third-party retailers.

The manufacturer seems confident about this formula and does not offer any bundled discounts, as seen in most other dietary supplements.

A 14-day free trial is offered for a charge equivalent to the shipping cost.

Enrolling in the free trial automatically enters you into the monthly auto-ship membership, which can be canceled within 18 days, or the full cost of the 30-day supply is billed.

You can buy Instaflex Joint formula for much less at and GNC. Buy Instaflex 14 capsules for half the price.

There is a 30-day money-back guarantee if you are dissatisfied with the joint supplement from Instaflex and wish to have it returned for a full refund.

The Bottom Line

Most treatment options for joint health available on the market are associated with undesirable side effects and can be costly.

Instaflex Advanced uses high-quality natural ingredients that a safe and relatively affordable.

Instaflex Advanced promises to work for even the worst joint pain-related inflammation or cartilage wear and tear as a doctor-formulated joint support supplement.

Reviews from actual users reveal that more people experienced the claimed benefits.

While not many users were pain-free within seven days of taking Instaflex Advanced consistently, they reported a significant improvement over time.

So far, there is no reason to doubt that Instaflex Advanced will improve stiff joints and reduce joint pain.

It is likely a better, more effective option than many joint health supplements.

Frequently Asked Questions (FAQs)

Should I take Instaflex Advanced?

Instaflex Advanced works to relieve joint pain fast. The advanced Instaflex joint formula boasts of a superior doctor-formulated blend of natural ingredients backed with premium research and clinical studies.

You may take Instaflex Advanced supplements to soothe paining knee, ease joint discomfort, and reverse joint stiffness.

Instaflex Joint Support is designed to nourish the joints, improve flexibility, and promote skeletal strength within 7 days.

Instaflex Advanced is most suitable for arthritis sufferers. It may also benefit anyone experiencing excessive pain and cramping, tender joints, or pain of sprains and strains.

Who should not take Instaflex Joint Support?

Instaflex does not outline any category of persons precluded from taking their Joints Support Supplement. However, as this formula may cause undesirable interactions with blood thinners and other medications, it may not be safe for some users.

Patients with heart diseases or a history of other clinical conditions face an increased risk of serious adverse effects when taking this supplement.

Instaflex Advanced (as with most dietary supplements) is not recommended for pregnant women and nursing mothers.

Anyone experiencing uncomfortable symptoms should cease taking the dietary supplement immediately.

Always consult a qualified healthcare provider before taking any dietary supplements and when experiencing any uncomfortable symptoms with use.

Can I take joint supplements after knee replacement surgery?

There’s no need to take joint supplements after replacement surgery. Some vitamin supplements and mineral boosts can help speed up recovery and maintain joint health after replacement surgery.

Supplementation with essential amino acids and Vitamin D could help patients recover faster after replacement surgery.

Some ingredients commonly used in joint relief such as glucosamine may feature in supplements for patients recovering from surgery.

Is there a safe and effective alternative to glucosamine for knee pain?

While glucosamine may provide some relief for knee osteoarthritis pain and help prevent joint disease associated with osteoarthritis other ingredients have proven to be twice as effective.

Regular use of glucosamine to treat joint pain in the knee may present some mild side effects including diarrhea and constipation.

Because most glucosamine is derived from shellfish, allergies may also present, leading to drowsiness, heartburn, headache, and skin reaction.

There are tons of glucosamine-free knee support supplements like Instaflex Advanced on the market.