Nucific Bio X4 Reviews: Side Effects, Ingredients, Complaints, & Customer Testimonials

Nucific Bio-x4 reviews

Welcome to my Nucific Bio X4 review…

It can be challenging to maintain a healthy diet and get regular exercise for many people.

We can only do so much with what little time we have.

Being healthy can feel like a luxury we can’t achieve.

This is where a dietary supplement comes in. There are a massive amount of weight loss supplements and procedures advertised to us.

They will promise us instant and quick results while doing nothing but taking some capsule, tea, or formula.

As much as we want to lose weight, being healthy by not compromising our digestion and immunity should be our priority.

Crash diets or laxatives are only quick fixes that have rebound effects.

What we need is something to aid us in achieving a healthy life and a healthy weight.

Bio X4, a probiotic-enriched weight loss supplement, claims to support us with this goal.

This review will evaluate its ingredients and the benefits and risks that come with it.

Nucific Bio X4 Review – Is it a Scam?

Bio-X4 Supplement

What is Nucific Bio X4?

Bio X4 is both a probiotic supplement and a weight loss supplement.

Nucific designed it to balance the digestive system and promote weight loss as a 4-in-1 weight management probiotic.

A mixture of 4 different blends with various benefits for the entire body.

Nucific claims that BioX4 will:

  • Improve digestive health and enhance the digestive process
  • Control food cravings and suppress appetite
  • Improve gut health and solve digestive issues
  • Boost metabolism and support fat loss

Bio X4 supplement contains active ingredients, including probiotic strains, digestive enzymes, and other plant extracts. It categorizes them in a four-ingredient blend to serve the purpose of its claims.

  • Probiotic Blend
  • Digestive Enzyme Blend
  • Weight Management Blend
  • Craving Control Blend

We will further delve into detail on each blend and ingredient below.

Bio X4 Ingredients

Probiotics are live microorganisms that are beneficial to gut bacteria.

They are associated with various health benefits.

Studies have shown the potential of beneficial bacteria in treating irritable bowel syndrome and gastrointestinal symptoms.

A healthy balance of gut bacteria can influence our immune system. The gut is associated with numerous diseases.

It has been associated with weight management, mood, brain health, and the digestive tract.

In addition, healthy gut bacteria are essential in nutrient and energy extraction from food.

We get our daily probiotics from fermented foods like yogurt and kimchi. But these foods do not assure a sufficient amount of healthy bacteria is absorbed in the gut.

Bio X4 contains 4 billion CFUs (colony-forming units) per capsule. This number tells how many bacteria are found in a supplement and its potency.

Probiotic Blend

it consists of two kinds of gut bacteria with different strains:


  • L.acidophilus
  • L.rhamnosus
  • L.plantarum


  • B.Lactis
  • B.animalis

Probiotics are not usually known for weight loss. It is more recognized in gut health and digestive health.

However, some studies have proven the potential of specific probiotic strains in weight loss.

Probiotics are recently gaining attention as potential anti-obesity ingredients.

Probiotics help you lose weight, but they can also have many benefits on health compared to usual weight loss pills.

Lactobacillus has been widely assessed in supporting proper digestion and overall health.

It has also been tested in treating antibiotic-associated diarrhea and in treating obesity.

L.acidophillus is a strain of Lactobacillus.

It produces lactic acid, which is found in dairy. It helps break down nutrients from food.

L.rhamnosus is linked with irritable bowel syndrome and digestion. L.plantarum acts as an antioxidant and improves digestive issues.

Bifidobacterium is often added to nutritional supplements to improve immunity and optimize digestion.

They are one of the significant strains found in the gastrointestinal tract.

B.lactis is often found in cheese or yogurt. 

It has been researched and proven effective in gut health and gastrointestinal symptoms, such as constipation.

On the other hand, B.animalis supported healthy gut bacteria, improved bowel function, and antibiotic-associated diarrhea.

In terms of the immune system, it increases resistance to respiratory infections.

Most probiotic strains are considered safe.

They have been tested in humans and have resulted in various mechanisms of action and effects. Side effects reported by consumers were mainly mild and seldom occurred.

Probiotics may cause gas, bloating, and stomach upset at first or for some individuals. Awareness of the type of strains included in your supplements is essential.

Bio X4 has indicated the type of species included in their ingredients. Most of these probiotics are found naturally in the gut.

A probiotic supplement like Bio X4 maintains its healthy balance.

There is scientific evidence proving their benefits for digestion and gut health but only a few studies on weight loss.

Eventually, further investigation will be required with better clinical trials to support its effects.

Digestive enzyme blend

It includes three types of digestive enzymes.

These are usually found in various fruits. First is amylase, which breaks down carbohydrates. Lipase breaks down fats and is essential for proper digestion.

The body produces both enzymes.

Therefore, there is insufficient evidence for the need to supplement these digestive enzymes for nutrient absorption or to ease digestion.

Usually, enzyme medications are prescribed when a person has a medical condition such as celiac disease that creates a deficiency.

Lastly, bromelain is an enzyme found in pineapple.

It helps the body digest protein and has various benefits. Hence, clinical studies have assessed its different therapeutic potential.

It is linked to effects on inflammation, pain, and respiratory health. Unfortunately, there is insufficient evidence to support their impact on weight loss.

Weight management blend

EGCG green tea extract

Bio X4 weight management composition includes EGCG green tea extract.

Claimed benefits of this ingredient are that it boosts metabolism and fat loss, while EGCG affects blood pressure and cholesterol.

Green tea extract is also a well-known antioxidant and weight loss tea. Studies that support these claims are from the caffeine in green tea.

However, the available studies on green tea extract have inconsistent results.

More human studies are needed to determine the potential of green tea extract to burn fat and weight loss.

Craving control blend

Slimaluma or Caralluma Fimbriata is claimed to ease unhealthy food cravings.

The Gencor company patents it, derived from a cactus in India. Caralluma Fimbriata is used for appetite suppression, but there are inconsistent results in studies made.

A clinical trial on overweight and obese individuals has assessed that Caralluma Fimbriata supplementation resulted in weight loss and reduced waist circumference.

However, the studies available for this ingredient have inconsistent results.


Nucific is the company that manufactures Bio X4 and is based in California.

It is a relatively recent company but provides sufficient information about its products.

They aim to help people achieve a good life and body with natural ingredients backed by scientific evidence.

The formulations created in Nucific are doctor-approved.

They have partnered with Dr. Amy Lee, a board-certified doctor by the American Board of Internal Medicine.

She is a member of the National Board of Physician Nutrition Specialists and the American Board of Obesity Medicine.

Additionally, Dr. Lee serves as a Chief Medical Officer in more than 30 clinics.

Nucific Bio X4 is not for

1) Preexisting conditions

Some of the ingredients in Bio X4 may interact with specific diseases and medications.

People with a severe medical condition or a compromised immune system are not suggested to take probiotics or weight loss supplements.

1) Pregnant or lactating women

Pregnant or lactating women should not take nutritional supplements without consulting medical professionals.

Ingredients in Bio X4 are not thoroughly studied for their safety in childbirth.

3) Ages under 18 years old

Bio X4 is made for adults who want to lose weight and have a compromised digestive system.

Weight loss or probiotic supplements are not recommended for children.

4) Unrealistic expectations

Bio X4 will not provide instant effects for weight loss.

The best way to maximize its effects is to consistently take it as directed and accompany it with a healthy lifestyle.

The Cons of Nucific Bio X4

1) Claims

There is insufficient scientific evidence for Bio X4 claims such as weight loss by appetite suppression, burning body fat, and boosting metabolism.

Nevertheless, Bio X4 is a good dietary supplement for digestive health.

Some studies support the benefits of Bio X4. Further investigation and consistent results in human clinical trials are needed.

2) Potency

Probiotic supplements’ effects and potency are dose and strain-specific.

Nucific did not include the information on Bio X4 about the dose per strain.

The side effects and potency of dietary supplements are dose-dependent.

The total probiotic blend CFUs may be insufficient to expect an effect from each strain. Consequentially, there would be a smaller chance of experiencing its side effects.

3) Prebiotics and Digestive enzymes

Bio X4 contains probiotics and digestive enzymes. However, most digestive health supplements contain a blend of probiotics and prebiotics.

Prebiotics complement the effects of probiotics as they help feed gut bacteria.

Additionally, the impact of digestive enzyme supplementation is not well studied.

Nucific Bio X4 Reviews from Customers

Most of the average reviews given on other Bio X4 reviews are 4 out of 5 stars. Amazon also has a high average rating, but a third-party seller sells it.

Bio X4 has a 4.6 average rating in 3570 reviews on their website.

Some customers reported minimal side effects like bloating, stomach pain, gas, and diarrhea.

Despite these complaints, most of the reviewers reported having lost weight and improved digestive symptoms.

I have to say I was skeptical, I watched a video I found while on Instagram and said “why not” and I have never been so amazed by anything before. It is literally the best thing I’ve ever tried.

After the first week, I just didn’t want to eat bad foods anymore and didn’t know why. Almost been a month […] I literally tell everyone I know having weight problems to try it. So thank you for this amazing product, you’ll want to get it monthly trust me(:”

“Not one to subscribe to just any weight loss program, I did some research and decided to give Bio-X4 a shot. Bio-X4 is the only product I’ve ever tried that actually works! I dropped weight with minimal changes to diet and zero exercises! The only drawback was I had to go buy some new skinny jeans ’cause the old ones were literally falling off – Justine”

The Pros of Nucific Bio X4

1) Formulation

Bio X4 is a doctor-approved formulation. Nucific is transparent in advertising its products. Dr. Amy Lee partnered with Nucific in formulating the ingredients of Bio X4.

They use natural ingredients tested at an independent, 3rd party facility—the effects of the ingredients in Bio X4 target weight loss and overall health.

Bio X4 provides different ingredients for various benefits to achieve a healthy weight without compromising your health.

2) Natural and safe

Nucific Bio X4 uses natural ingredients; every capsule is gluten-free and allergen-free.

Additionally, it contains no preservatives, colorings, or synthetic fillers. Their packaging is also environmental-friendly.

Bio X4 is considered safe, and only minor side effects may occur.

These effects eventually subside or disappear when Bio X4 is discontinued. However, it is essential to inform your healthcare provider if Bio X4 is for you.

3) Informative website

The company prides itself in helping people improve their health by aiding nutrition.

They also support charities and environmental-friendly pursuits.

Their official website is easy to navigate and has extensive information about their products and blogs to assist you with your health concerns.

Nucific is also transparent about its formulations.

5) 90-day Refund Guarantee

Nucific’s 90-day refund guarantee covers every order. You can contact the company on their official website for your request and send back an empty bottle for a refund.

What to watch out for

If you experience persistent digestive problems and unintended weight gain, consult a doctor to provide medical advice.

These symptoms may be caused by certain medical conditions that need proper diagnosis and medical treatment.

Remember that dietary supplements are not intended to treat or cure serious diseases.

Every individual has different digestive systems and gut compositions.

Many factors will influence the efficacy of Bio X4, and results will vary for every person. Your lifestyle and condition will influence its benefits for weight loss and digestion.

A third-party seller sells Bio X4 on Amazon, but they are not affiliated with Nucific. The authenticity of their products is not assured.

Where to buy Nucific Bio X4

Bio X4 is only available on Nucific’s official website.

It is not available in-store or in other online stores. A bottle of Bio X4 is sold in single, three, and six bottles. The price is discounted if you order in bulk for a 3 or 6-bottle supply.

Verdict on Nucific Bio X4

Bio X4 is a better option for weight loss than intensive laxatives or highly caffeinated supplements. It benefits digestive health, gut flora, and the immune system.

Bio X4 includes natural ingredients that are gluten-free and allergen-free.

The claims of Nucific on Bio X4 have been studied in humans.

Nevertheless, more clinical trials with consistent results and improved methods should be conducted.

The specific dose of each ingredient in Bio X4 should also be provided. Even so, the total amount of each blend can be considered safe.

It would be better evaluated for its potency and safety if Nucific stated the amount of each strain and the digestive enzyme.

The long-term use of Bio X4 will be beneficial for a healthy lifestyle.

It does not contain intensive weight-loss ingredients that can cause harmful effects. It is more sustainable than other supplements.

Still, its weight loss effects may have lower potency, but its digestive benefits are well supported.

It is better to accompany Bio X4 with a healthy diet and regular exercise to achieve your weight loss goals.

Regardless, you should always consult a healthcare provider before taking any supplements. The information provided in this review is for informational purposes only.

Frequently Asked Questions (FAQs)

How do I take Bio X4?

Take one capsule of Bio X4 with each meal, three times per day. You can take up to two capsules per meal, but do not exceed more than six capsules of Bio X4.

What will happen if I miss a day of Bio X4?

If you miss one capsule of Bio X4 or an entire day, continue as usual the next day.

How long does it take for Bio X4 to work?

It is advised to take 60 days to 90 days for Bio X4 to work fully. Preferably, you will need to take it consistently on a daily basis. This will allow your body to build a sufficient amount of its ingredients in your system.

Is Bio X4 safe?

Bio X4 is generally safe. It has minimal side effects such as bloating and flatulence. Nevertheless, these effects will eventually subside or disappear if discontinued.

Always consult your healthcare provider if you experience persistent side effects or before taking any supplement.

What is in Bio X4?

It contains probiotics, natural enzymes, and plant extracts. A bottle of Bio X4 includes 90 capsules that will last for a month.

What does Bio X4 do?

Bio X4 is a 4-in-1 weight management probiotic supplement. It has ingredients that benefit digestion and weight loss.

Is Bio X4 a scam?

Bio X4 is a legitimate product manufactured by Nucific. The company is third-party tested and has doctor-approved formulations. Like any supplement, Bio X4 results will vary per individual.