Home Product Guides Best Over The Counter Digestive Enzymes of 2021 – Super Supplements For Gas & Bloating

Best Over The Counter Digestive Enzymes of 2021 – Super Supplements For Gas & Bloating

by Decyry Jhoy Serrano, RPh
Published: Last Updated on

So, what’s the best digest enzyme on the marketplace right now?

You see, when you eat a lot of pizza, pasta, and all of your favorite snacks, your digestive system works double.

However, when you have digestive problems, your digestive system cannot break down food properly as the digestive enzyme activity is low.

In fact, more than 22 million acute digestive health problems have been reported in the United States, causing bloating, irritable bowel syndrome, gastrointestinal distress, and other gastrointestinal symptoms.

Fortunately, there are available digestive enzyme supplements and in this article, you will be able to find the best digestive enzyme supplements that will suit you and your digestive system’s needs.

Top Digestive Enzymes – Quick List

Best Digestive Enzyme Supplements – The Top Brand & Blend

1) Bioptimizers MassZymes Enzymes – Best Overall


If you ever feel bloated even just after snacking a small amount of food or carbs, it is about time to get a new digestive aid.

Moreover, if you are a bodybuilder or an athlete and no matter how much reduction of protein shake you do, there is no improvement on your digestive health, a new digestive transformation has to be done!

So, what is this digestive enzyme supplement product I am talking about?

This digestive enzyme supplement is extracted from Panax ginseng and Astragalus using an innovative processing technique.

One good thing about this product is that having it will not require you to consume any more protein to get those gains!

So, if you are ready to get this extreme and amazing digestive enzyme product that makes your protein consumption x3, read more about its amazing features below!


  • Aids in protein and food digestion
  • Improves amino acids (AA) absorption up to 50%
  • Comes with critical growth-enhancing AA
  • Helps in growing bigger, stronger, and healthier muscle fibers
  • Comes with up to 66% more muscle-building AA
  • Able to break down food up into 200% protein to AA
  • Made from natural digestive enzymes
  • Plant based enzymes
  • Up-regulates protein transport
  • Reduces the inflammation and oxidative stress after working out
  • Zero adverse effects
  • Pre-workout energy
  • Decreases the need to sleep
  • Enhances immune system
  • Improves mental health, focus, and overall health


  • Some nutrients on MassZymes™ product that do not make it to the intestinal cells may be flushed down

Because of its one disadvantage, the manufacturer formulated MassZymes plus AstraZymes™ for multiplication of potency and more benefits such as the following:

  • Boost absorption of essential vitamins up to 50%
  • Increase joint-protecting benefits for up to 42%
  • Heighten glucose absorption for up to 55%
  • Repair damaged intestinal wall
  • Improve gut health
  • Increases energy for up to 18%

Compared to others, this product is most beneficial to those who want to get ready before burning out some muscles at the gym.

Additionally, it does not just improve physical health but also improves the mental health of the consumer.

Formulation, Dosage, and Active Ingredients

Each capsule contains 100,000 HUTs of protease and 1 capsule per day is required.

This product’s active ingredients are the following:

Protease 6.0, 4.5 And 3.0, Peptidase, Amylase, Bromelain, A-galactosidase, Glucoamylase, Lactase, Lipase, Invertase, Malt Diastase, Phytase, Phenitase, Pectinase, Hemicellulase, Beta-Glucanase, And Astrazyme™.


  1. “This product can be used to manage gut inflammation and promote healthy gut bacteria”Vince Del Monte, Bodybuilder
  2. “This product does not just digest the undigested food but it helps the body break and absorb it”Mike Westerdal
  3. “Perfect for the whole family including my kids”Elliot Hulse, Pro Strongman

2) Amy Myers MD Complete Enzymes

Complete Enzymes

As you age, your digestive enzymes weaken.

Fortunately, coming from its name, Complete Enzymes, this product comes with a full-spectrum enzyme blend that does not just aid in poor digestion but also helps in repairing the intestine due to inflammation.


  • Perfect for those with food sensitivities
  • Helps those patients who are having troubles in absorbing nutrients
  • Creates an environment to make microbiomes healthier
  • Support digestion
  • Restore optimal gut function
  • Helps in breaking down gluten, peptides, proteins, carbs, sugar found in sweets, and other fibers
  • Can be used by patients with Celiac disease


  • Cannot be consumed by patients who are sensitive to eggs

This product is perfect for those with Celiac disease. Consult a medical professional before taking this product for further information and evaluation.

Formulation, Dosage, and Active Ingredients

Each bottle of this digestive enzyme supplement contains 120 capsules.

It is suggested to take 2 capsules before each meal.

This product’s active ingredients are the following:

amylase, alpha-amylase, glucoamylase, lactase, sucrase, maltase, pullulanase, lipase, lysozyme, Serratia peptidase, cellulase, hemicellulase/pectinase/phytase complex, beta-glucanase, α-galactosidase, galactomannan, protein, and peptide-specific enzymes.


  1. “Truly a life-saver”Jane K.
  2. “No more bloating, stomach pain, or nausea! Best taken before and after meal”Rebecca G.
  3. “Remarkable difference in my health!”Martin R.
  4. “Products are skillfully done. Flatter stomach!”Neil N.

3) 1MD Enzyme MD®


EnzymeMD comes with broad-spectrum digestive support and it is perfect for individuals who need to relieve their bloatedness just after snacking!

Additionally, it comes with 18 highly potent, best digestive enzymes.

Moreover, these key enzymes are plant-based enzymes!

Aside from these, it also comes with probiotics.

As said, when you snack a lot, your body works double.

But with this product, your body will not have to work extra as the product will do the work for you.

Moving on, what are its benefits?


  • Developed by a Board-Certificate Gastroenterologist
  • Fast-acting
  • Aids in restoring long-term digestive health
  • Helps in eliminating toxins due to the probiotic S. boulardii
  • Gluten-free
  • Not made with dairy products
  • Made with 100% non-GMO


  • Diarrhea and cramps may occur

One of the advantages of using this product is that it provides fast-acting relief to any kind of bloating.

In just a few minutes, all the feeling of bloatedness will be gone!

Formulation, Dosage, and Active Ingredients

It is recommended to take this product for at least 3 months and an individual can take 1 or 2 capsules 20 minutes before a meal.

This product’s active ingredients are the following:

Saccharomyces boulardii, Alpha-amylase, Bromelain, Peptidase, Glucoamylase, Protease (pH 2-3), Protease (pH 3-6), Protease (pH 6-9), Papain, α-galactosidase, Cellulase, Lipase, Beta-glucanase, Phytase, Invertase, Maltase, Hemicellulase, Xylanase, and Lactase.


  1. “I never had any digestive issues with any food. No more food problems!”Rebecca O.
  2. “Less burping within the first week.”M. Redding
  3. “No more abnormal results on my lab tests including kidney-related results.”N. Alvarez

4) Probulin Daily Enzymes

Probulin Digestive Enzymes

If even simple foods make it hard for you to digest, this digestive enzyme supplement will surely be of great help.

It comes with probiotics that enhance your daily routine.

In fact, even broccoli and cabbage could be digested by these probiotics easily!

If you are an individual who is having occasional bloating, gas, and constipation, take a look at the benefits of this product below.


  • Broad-spectrum, plant-based, and probiotic-based digestive enzymes
  • Easily digest gluten and dairy products
  • Potent and stable confirmed by a third-party laboratory
  • Doctor-formulated
  • Shelf-stable
  • No refrigeration of the formulated multiple enzymes required
  • Gluten-free and dairy-free
  • Soy-free
  • Made with 100% non-GMO

This product can be stored whenever, wherever.

So, no need to worry about melting capsules and discolorations as this product can be stored anywhere for daily use.

Formulation, Dosage, and Active Ingredients

Each bottle of Probulin Daily Enzymes contains 90 or 120 capsules. It is suggested to take 1 capsule before each meal.

This product’s active ingredients are the following:

Makzyme Pro Enzyme Blend, Protease, Papain, Peptidase, Amylase, Glucoamylase, Hemicellulase, Invertase, Maltase, Phytase, Xylanase, α-galactosidase, Beta-glucanase, Cellulase, Pectinase, Lipase, and Lactase.

Few Reviews from Customers

  1. “I always feel that something good is happening in my gut when I take them!”
  2. “Best digestive enzymes that truly works”
  3. “Perfect product and fast shopping timeline!”

5) Enzymedica Digestive Gold™

Enzymedica digest gold

Powered by Thera-blend™, this product digests a large amount of food you eat during holidays.

Having this product allows you to eat without worrying about any digestive issues!

Moreover, it comes with ATPro™ that helps you be more energetic as you take it with every meal.


  • Vegan
  • Gluten-free and dairy-free
  • Soy-free
  • Made with 100% non-GMO
  • Tested and certified Clean Label Project


  • Quite expensive but worth to buy
  • No pre and pro probiotics

One of the advantages of this product is that patients who are regularly experiencing bloatedness can use it regularly as well.

Surely, no more bloating or gas will be experienced even when you are just consuming a very small amount of food.

Formulation, Dosage, and Active Ingredients

It is suggested to take 1 or more capsules before each meal.

This product’s active ingredients are the following:

Amylase, Protease, Glucoamylase, ATP, Alpha Lipoic Acid, Magnesium Citrate  CoQ10, Alpha-Galactosidase, Cellulase, Lipase, Lactase, Beta-Glucanase, Maltase, Xylanase, Invertase, Pectinase, and Hemicellulase.

Consult a doctor or a healthcare professional if you are pregnant or with other health conditions.

Customer Reviews

  1. “I do not experience any adverse effects”Amazon buyer
  2. “Gold standard.”Shannon
  3. “Because of small-sized capsules, I find them easy to swallow”Sandra G.

6) Now Super Enzymes

NOW super enzymes

This product is made from a comprehensive enzyme blend formulation that gives digestive support.

Additionally, the digestive enzymes on this product also support healthy digestion.

One capsule will already optimize the breakdown of the foods you snacked!


  • Vegan
  • Gluten-free and dairy-free
  • Soy-free
  • Shellfish-free
  • Made with 100% non-GMO
  • Tested and certified Clean Label Project


  • Can cause mild diarrhea

Compared to others, this product is the best option for those looking for a great but inexpensive, but best digestive enzyme. At a low cost, your digestive system will have quality digestive tract support every time you use this product.

Formulation, Dosage, and Active Ingredients

It is suggested to take 1 or more capsules before each meal.

This product’s active ingredients are the following:

Bromelain, Ox bile, animal derived enzymes such as Pancreatin, Papain, Cellulose, Gelatin, Magnesium stearate, and silica.

Consult a doctor or a healthcare professional if you are pregnant or with other health conditions.

Testimonials from Customers

  1. “This product’s digestive enzymes can turn liver cirrhosis around!”
  2. “Improvements are seen after a week”
  3. “The digestive enzymes of this product improved the consistency of my stool while relieving my bloatedness”

7) Pure Encapsulations Digestive Enzymes Ultra

PURE digestive enzymes

The acid in the stomach affects the abortion of a medicine.

Fortunately, the pure encapsulations digestive enzymes ultra is perfect for all pH ranges!

One great feature of this product is that it is unflavored.

So, if you are sensitive to flavors and you want optimal digestion and bioavailable product, this one is perfect for you.


  • Helps in nutrient absorption
  • Boost digestion of food
  • Formulation of dietary supplements is done based on research
  • Broad-profile digestive enzymes
  • Made from pure and quality materials and ingredients
  • Free from eggs and peanuts
  • Gluten-free
  • Flavor and sweetener-free
  • Made with 100% non-GMO
  • No preservatives


  • Kind of expensive

Every human’s stomach has a different pH or acid value.

For patients who are having digestive tract problems but are acidic, they may find comfort with this product.

No matter how high your pH or acid is, this product will surely work for you. Think about this advantage!

Formulation, Dosage, and Active Ingredients

Each bottle of this product contains 180 capsules. It is suggested to take 2 capsules before each meal.

This product’s active ingredients are the following:

  • Amylase
  • Protease
  • Glucoamylase
  • Lactase
  • Lipase
  • Beta-glucanase
  • Invertase
  • Cellulase
  • A-galactosidase
  • Phytase
  • Hemicellulase
  • Cellulose
  • Water
  • Ascorbyl palmitate and
  • Hypoallergenic plant fiber.

Consult a doctor or a healthcare professional if you are pregnant or with other health conditions.


  1. “Capsules size is convenient”G. Beauty
  2. “This product’s digestive enzymes helped me to have a faster and better digestion”Aishna A.
  3. “Expensive but effective”Cash C.

8) Zenwise Health Digestive Enzymes

Zenwise digestive enzymes

This product comes with prebiotics and probiotics supplements and it is perfect for men and women.

Aside from providing better digestion, it also enhances the immune system of a person.

Moreover, these digestive enzymes digest dairy products faster.

In fact, even spicy, raw, and processed foods can be digested without having a hard time!


  • Immune-boosting probiotic
  • Digestive enzymes work to absorb nutrients more
  • Advanced Multi Enzyme System
  • Comprehensive support for the digestive system
  • AVA-certified
  • Comes with 1 billion CFUs from 10-strain probiotics
  • Comes with spore-forming probiotics
  • Made from sea vegetable complex

This product is most advantageous for vegans!

It is made from pure vegetable ingredients with immune system-boosting effects.

Formulation, Dosage, and Active Ingredients

Each bottle of this product contains 180 capsules. It is suggested to take 1 capsule before each meal.

This product’s active ingredients are the following:

Inulin, Glucoamylase, Amylase, Bromelain, Cellulase, Invertase, Lactase, Protease, Papain, Lipase, Maltase, Papaya Fruit Powder, Apple Pectin, Ginger Root Powder, Nori, Wakame, Bladderwrack Extract, Fennel Seed Powder, Turmeric Root Powder, Peppermint Leaf Extract, Healthy bacteria including Bacillus subtilis DE111, Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium animalis lactis, Bifidobacterium bifidum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus Plantarum, Lactobacillus salivarius, Bifidobacterium breve, Microcrystalline Cellulose, Hypromellose, Water, Medium Chain Triglycerides, Magnesium Stearate, Silica, and Sulfites.

Consult a doctor or a healthcare professional if you are pregnant or with other health conditions.

Customer Reviews

  1. “Miracle pills changed my life!”Joseph K.
  2. “Life-changing product!”Amazon customer
  3. “I see myself purchasing again.”Sparkle

Frequently Asked Questions (FAQs)

Are digestive enzymes good for you?

Digestive enzymes, the ones that help digest food, are perfect not just for the digestive system but also for the overall health of a patient.
They do not just help our small intestine digest the unhealthy or healthy food we eat but it also makes our body break and absorb the nutrients of the digested foods.

There are a lot of digestive enzyme brands available. Choose the best that suits your condition.

Is it safe to take the best digestive enzyme supplements daily?

Different digestive enzymes are formulated by professionals and for this reason, it is safe to say that these digestive enzymes can be consumed daily.

However, for safer consumption, it is important to seek medical professional guidance to optimize the use of a digestive enzyme supplement.

How long should I take digestive enzymes?

There is no specific timeline when taking digestive enzymes.

Taking these digestive enzyme supplements depends on the gut health or condition of the patient.

Moreover, patients can actually take a digestive enzyme supplement daily or as recommended by a medical professional, especially when naturally produced enzymes are not enough.

Who can use a digestive enzyme supplement?

Generally, digestive enzyme supplementation is used by people who are needing extra gut digestion support, especially those who cannot digest large amounts of all the healthy food or unhealthy food they eat.

A person who wants to get optimal nutrient absorption may choose a specific enzyme brand.

Moreover, a healthcare professional can help in choosing the best digestive enzymes for you.

When is the best time to take digestive enzymes?

Most digestive enzymes can be taken before and/or after meals.

Usually, these important enzymes are taken before mealtime to give way for them to activate.

However, it is important to know that taking multiple digestive enzymes during or after mealtime is also great as they can assist more with the reduction of the inflammation of the intestine and improve gut health.

Are digestive enzyme supplements safe to be taken by all ages?

As long as the consumer is not allergic to any of the ingredients of the digestive enzymes, these supplements are safe to be taken by children, the elderly, and pregnant women.

However, it is always recommended to consult a doctor or a healthcare professional to get the best digestive enzymes for you, especially if the patient is contraindicated with the product.

What is the best digestive enzyme supplement?

All digestive enzyme products are made with specific enzymes that can suit the needs of every patient in order to promote healthy digestion.

To know the right digestive supplement for you, it is advised to talk to a healthcare professional.

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